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个人简介
Prof Charles Swanton is a clinician scientist, focusing his work on understanding the challenges inherent in the management of metastatic cancer and their drug resistant and incurable nature.
Prof Charles Swanton completed his PhD in 1998 at the Imperial Cancer Research Fund Laboratories on the UCL MBPhD programme under the supervision of Nic Jones before completing his medical oncology and CRUK funded post-doctoral clinician scientist training in 2008 with Julian Downward.
Prof Charles Swanton was appointed CRUK senior clinical research fellow and Group Leader of the Translational Cancer Therapeutics laboratory at the London Research Institute and consultant medical oncologist at the Royal Marsden Hospital in 2008. He was appointed Fellow of the Royal College of Physicians, Chair in Personalised Cancer Medicine at the UCL Cancer Institute and Consultant Thoracic Medical Oncologist at UCL Hospitals in 2011.
Prof Charles Swanton is the Chief Investigator of the CRUK TRACERx clinical study to decipher lung cancer evolution and is the Co-director of the CRUK Lung Cancer Centre of Excellence.
Prof Charles Swanton was appointed Fellow of the European Academy of Cancer Sciences, awarded the Goulstonian lecture and Graham Bull Prize for Clinical Sciences in 2013 and the Journal of Pathology Jass Prize in 2014. He has published over 120 papers, with first or senior author publications in the New England Journal of Medicine, Nature, Nature Genetics, Cancer Discovery, Cancer Cell, Science, Science Translational Medicine and the Lancet Oncology. His work has led to insight into genomic diversity within cancers (intratumour heterogeneity) and molecular mechanisms driving cancer branched evolution.
His multidisciplinary team has discovered that DNA replication stress, cancer genome doubling events and the APOBEC cytidine deaminase family precipitate cancer diversity, accelerating cancer evolution, providing the substrate for cancer drug resistance and treatment failure. Prof Charles Swanton was awarded the Stand Up 2 Cancer Laura Ziskin translational cancer research award in 2015 and the Biochemical Society 2016 GSK prize in recognition of distinguished research leading to new advances in medical science. He was made a Fellow of the Academy of Medical Sciences in 2015.
研究兴趣
论文共 770 篇作者统计合作学者相似作者
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Katey S S Enfield,Emma Colliver,Claudia S Y Lee,Alastair Magness, David A Moore, Monica Sivakumar,Kristiana Grigoriadis,Oriol Pich,Takahiro Karasaki,Philip S Hobson,Dina Levi,Selvaraju Veeriah,
Cancer discovery (2024)
Francisco Gimeno-Valiente, Carla Castignani, Elizabeth Cadieux L. Cadieux, Nana E. Mensah,Olga Chervova,Mariam Jamal-Hanjani,Nicholas McGranahan,Stephan Beck,Jonas Demeulemeester,Miljana Tanic,Charles Swanton, Peter Van Loo,
Cancer Researchno. 6_Supplement (2024): 1611-1611
Hermaleigh Townsley, Joshua Gahir,Timothy W Russell, David Greenwood,Edward J Carr, Matala Dyke,Lorin Adams, Murad Miah,Bobbi Clayton, Callie Smith, Mauro Miranda,Harriet V Mears,
Giulia Dowgier, Agnieszka Hobbs, David Greenwood,Marianne Shawe-Taylor,Phoebe Stevenson-Leggett, James Bazire, Rebecca Penn,Ruth Harvey,Vincenzo Libri,George Kassiotis,Steve Gamblin,Nicola S Lewis,
crossref(2024)
PLOS BIOLOGYno. 1 (2024): e3002463-e3002463
Charles Swanton, Matthew Margolis,Earl Hubbell,Kathryn N. Kurtzman, Stephannie Shih,Oliver Venn, Michael Seiden
Cancer Researchno. 6_Supplement (2024): 3895-3895
Iris H.R. Yoon,Robert Jenkins,Emma Colliver,Hanyun Zhang,David Novo,David Moore, Zoe Ramsden,Antonio Rullan,Xiao Fu,Yinyin Yuan,Heather A. Harrington,Charles Swanton,
biorxiv(2024)
Marianne Shawe-Taylor, David Greenwood, Agnieszka Hobbs,Giulia Dowgier, Rebecca Penn,Theo Sanderson, Phoebe Stevenson-Leggett, James Bazire,Ruth Harvey,Vincenzo Libri,George Kassiotis,Steve Gamblin,
The Lancetno. 10432 (2024): 1133-1136
Charles Swanton, Elsa Bernard, Chris Abbosh,Fabrice André,Johan Auwerx,Allan Balmain,Dafna Bar-Sagi,René Bernards,Susan Bullman,James DeGregori, Catherine Elliott,Ayelet Erez,
Cellno. 7 (2024): 1589-1616
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