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Dr. Parkos’ research interests focus on basic mechanisms of epithelial-immune cell interactions and the impact on mucosal homeostasis. Using in-vitro and in-vivo approaches, the lab is studying the molecular basis of leukocyte migration across mucosal epithelia as well as the impact of inflammation on epithelial barrier function as observed in pathologic conditions such as ulcerative colitis and Crohn’s disease. Dr. Parkos and his team have elucidated the roles of many epithelial and neutrophil proteins in regulating leukocyte trafficking across the intestinal mucosa that include adhesion/signaling molecules such as CD11b/CD18, CD47, SIRPalpha, junctional adhesion molecules (JAMs), and cell surface glycans. Recent studies by the group have provided important insights into fundamental mechanisms of how these receptors regulate mucosal homeostasis during health and disease. Current projects in the laboratory are using complementary in-vitro and in-vivo approaches to examine the role of JAM family members in the regulation of epithelial barrier and leukocyte migration, characterizing the signaling events that occur between leukocytes and epithelial cells that serve to control leukocyte transmigration and epithelial permeability, and elucidating the structural basis of protein interactions that regulate these responses.
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Nature Communicationsno. 1 (2023): 1-22
PNAS nexusno. 5 (2022): pgac249-pgac249
Mario Amatruda,Candice Chapouly, Viola Woo,Farinaz Safavi,Joy Zhang,David Dai,Anthony Therattil, Chang Moon, Jorge Villavicencio,Alexandra Gordon,Charles Parkos,Sam Horng
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2021)
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