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Dr. Gerfen studies the functional organization of the cerebral cortex and basal ganglia. The basal ganglia are involved in transforming activity in the cerebral cortex into directed behavior. Using neuroanatomical tracing techniques, he mapped the connections of the circuits of this system, characterizing the compartmental nature of the input-output organization of the striatum, which is the main nucleus of the basal ganglia. His work established that the D1 and D2 dopamine receptors are segregated into two main pathways within the basal ganglia circuits. This finding forms a cornerstone of the predominant model of neurologic disorders affected by diseases of the basal ganglia, including movement disorders such as Parkinson's disease, chorea, and dystonia, and mental disorders such as attention deficit hyperactivity disorder and depression.
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论文共 166 篇作者统计合作学者相似作者
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Shana E. Silverstein, Ruairi O’Sullivan,Olena Bukalo,Dipanwita Pati, Julia A. Schaffer,Aaron Limoges, Leo Zsembik,Takayuki Yoshida, John J. O’Malley,Ronald F. Paletzki, Abby G. Lieberman,Mio Nonaka,
NATURE COMMUNICATIONSno. 1 (2023)
Alyse Thomas,Weiguo Yang, Catherine Wang,Sri Laasya Tipparaju,Guang Chen, Brennan Sullivan, Kylie Swiekatowski, Mahima Tatam,Charles Gerfen,Nuo Li
bioRxiv : the preprint server for biology (2023)
Shouvik Majumder, Koichi Hirokawa,Zidan Yang,Ronald Paletzki,Charles R Gerfen,Lorenzo Fontolan,Sandro Romani,Anant Jain,Ryohei Yasuda,Hidehiko K Inagaki
bioRxiv : the preprint server for biology (2023)
Neuronno. 14 (2023): 2247-2257.e7
bioRxiv : the preprint server for biology (2023)
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Alyse Thomas,Weiguo Yang, Catherine Wang,Sri Laasya Tipparaju,Guang Chen, Brennan Sullivan, Kylie Swiekatowski, Mahima Tatam,Charles Gerfen,Nuo Li
Nature communicationsno. 1 (2023): 7358-22
bioRxiv : the preprint server for biology (2023)
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