基本信息
浏览量:27
职业迁徙
个人简介
RESEARCH AREA
NAD metabolomics & systems biology
Coronavirus biology
Postpartum, lactation & neurodevelopment
Diabesity & fatty liver
Genotype-specific cancer targeting
Charles Brenner is the Alfred E Mann Family Foundation Chair in Diabetes and Cancer Metabolism in the Department of Diabetes & Cancer Metabolism. His laboratory focuses on disturbances in nicotinamide adenine dinucleotide (NAD), the central catalyst of metabolism, in diseases and conditions of metabolic stress.
Among his most significant discoveries, he identified nicotinamide riboside as an unanticipated vitamin precursor of NAD. He also developed a quantitative metabolomic technology that allowed him to discover that the NAD system is disturbed by many diseases and conditions of metabolic stress including diabetes and cancer.
Specifically, Dr. Brenner and colleagues have found that in animal models of fatty liver, type 2 diabetes, diabetic and chemotherapeutic neuropathy, central brain injury, heart failure, postpartum and coronavirus infection, the NAD system is disturbed. In these models, provision of nicotinamide riboside is highly protective.
Dr. Brenner led the team that conducted the first clinical trial of nicotinamide riboside establishing safe oral availability and has participated in trials establishing safety and potential activities of nicotinamide riboside in clearance of liver fat and depression of common markers of inflammation. He continues to research how the NAD system is dysregulated as a function of postpartum, coronavirus infection, inflammatory conditions, diabesity and specific malignancies with the dual goals of defining mechanisms of biological regulation and developing safe preventative and therapeutic interventions for people.
研究兴趣
论文共 290 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Scienceno. 6689 (2024): 1300-1300
Journal of Biological Chemistryno. 3 (2024)
The EMBO journalno. 3 (2024): 362-390
Science (New York, N.Y.)no. 6689 (2024): 1300-1300
GeroScienceno. 1 (2024): 665-682
James A. Timmons,Charles Brenner
Cellno. 5 (2024): 1101-1102
Journal of Biological Chemistryno. 3 (2023): 103858-S455
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn