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个人简介
Dr. Lu's laboratory(link is external and opens in a new window) is interested in understanding basic mechanisms governing chromatin organization and access during normal and cancer development. Eukaryotic cells develop sophisticated mechanisms to package and access their genetic information, and recent studies uncover that proteins involved in genome regulation are frequently altered in human developmental disorders and cancers. These findings raise the questions of whether and how aberrant chromatin landscape facilitates human disease development. Our previous work have largely focused on hotspot, gain-of-function mutations in chromatin modulators and regulators, including IDH1/2 and histone H3, that are frequently identified in a number of adult and pediatric cancer types. Collectively we have delineated the biochemical mechanisms by which these mutations alter global chromatin landscape. We also demonstrated that chromatin mutations are pro-oncogenic through blockade of cellular differentiation. These findings provide compelling evidence for a causal role of chromatin dysregulation in oncogenesis, and propose a novel pathway of cancer initiation through accumulation of hyper-proliferative and differentiation-refractory tissue progenitor cells driven by epigenome abnormality.
研究兴趣
论文共 109 篇作者统计合作学者相似作者
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Kristjan H Gretarsson,Stephen Abini-Agbomson,Susan L Gloor,Daniel N Weinberg, Jamie L McCuiston, Vishnu Udayakumar Sunitha Kumary,Allison R Hickman,Varun Sahu,Rachel Lee,Xinjing Xu, Natalie Lipieta, Samuel Flashner,
bioRxiv : the preprint server for biology (2024)
Dimitris Karagiannis,Warren Wu,Albert Li,Makiko Hayashi,Xiao Chen, Michaela Yip, Vaibhav Mangipudy,Xinjing Xu,Francisco J. Sanchez-Rivera,Yadira M. Soto-Feliciano,Jiangbin Ye,Thales Papagiannakopoulos,
CELL REPORTSno. 1 (2024): 113629-113629
Gerry A. Shipman,Reinnier Padilla,Cynthia Horth,Bo Hu,Eric Bareke, Francisca N. Vitorino, Joanna M. Gongora,Benjamin A. Garcia,Chao Lu,Jacek Majewski
bioRxiv : the preprint server for biology (2023)
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Jonathan F Thomas,Marco Igor Valencia-Sánchez,Simone Tamburri,Susan L Gloor, Samantha Rustichelli, Victoria Godínez-López,Pablo De Ioannes,Rachel Lee,Stephen Abini-Agbomson, Kristjan Gretarsson,Jonathan M Burg,Allison R Hickman,
bioRxiv : the preprint server for biology (2023)
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biorxiv(2023)
Yongchun Zhang,Dimitris Karagiannis,Helu Liu,Mi Lin,Yinshan Fang,Ming Jiang,Xiao Chen,Supriya Suresh, Haidi Huang,Junjun She,Feiyu Shi, Patrick Yang,
bioRxiv : the preprint server for biology (2023)
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Natureno. 7987 (2023): 643-651
bioRxiv : the preprint server for biology (2023)
Xiao Chen,Yinglu Li, Fang Zhu,Xinjing Xu, Brian Estrella, Manuel A. Pazos II,John T. McGuire,Dimitris Karagiannis,Varun Sahu, Mustafo Mustafokulov,Claudio Scuoppo,Francisco J. Sánchez-Rivera,
Nature communicationsno. 1 (2023): 4259-17
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