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With the advent of genomic technologies, vast areas of developmental biology have become accessible to exploration. Research in Celeste's lab focuses on questions concerning patterning and shape -- how individual cells within a sheet become different from each other and how they then work together to create an organ. These processes are important for the normal development of an organism and it is these processes that are modulated to create new forms. To investigate patterning and shape, we use the model system Drosophila melanogaster, which has outstanding genetic tools that allow temporal and spatial manipulation of gene activity within individual cells. Genome sequence data from wild populations, nine related Drosophila species, and several distant insects facilitate identification of evolutionarily important sequences and this information is coupled to a vast literature on these species' adaptive morphological traits. Celeste has developed a culture system that allows live imaging of developmental events; this tool enables investigation of the mechanisms that execute development and that alter pattern and shape to create evolutionarily diverse forms. Understanding how pattern and shape create form is important because imperfections in these processes cause defects that affect an estimated 3% of live births.
With the advent of genomic technologies, vast areas of developmental biology have become accessible to exploration. Research in Celeste's lab focuses on questions concerning patterning and shape -- how individual cells within a sheet become different from each other and how they then work together to create an organ. These processes are important for the normal development of an organism and it is these processes that are modulated to create new forms. To investigate patterning and shape, we use the model system Drosophila melanogaster, which has outstanding genetic tools that allow temporal and spatial manipulation of gene activity within individual cells. Genome sequence data from wild populations, nine related Drosophila species, and several distant insects facilitate identification of evolutionarily important sequences and this information is coupled to a vast literature on these species' adaptive morphological traits. Celeste has developed a culture system that allows live imaging of developmental events; this tool enables investigation of the mechanisms that execute development and that alter pattern and shape to create evolutionarily diverse forms. Understanding how pattern and shape create form is important because imperfections in these processes cause defects that affect an estimated 3% of live births.
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