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The research focuses on understanding key molecular mechanisms in cancer, using a combination of large-scale omic approaches, focused mechanistic experiments andin vivo studies. The goal is to understand critical cancer pathways so that we can suggest better cancer treatments and preventive approaches and biomarkers to be tested and developed for clinical use.
The hormone estrogen can increase the risk of breast cancer, while simultaneously protect against colon cancer. It is not understood exactly how, but if we can achieve a detailed knowledge of this mechanism, we would be able to design approaches that can protect against colon cancer while not promoting breast cancer, and we could also improve the treatment of breast cancer. Estrogenic signaling is mediated by the estrogen receptors, ERalpha and ERbeta. They are ligand-activated nuclear receptors and as such excellent therapeutic targets. My research focuses on the estrogen-induced pathways in breast and colon cancer, and the impact that environmental or dietary estrogenic exposure may have.
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Christian Sommerauer,Carlos J Gallardo-Dodd,Christina Savva,Linnea Hases,Madeleine Birgersson,Rajitha Indukuri,Joanne X Shen,Pablo Carravilla,Keyi Geng,Jonas Nørskov Søndergaard, Clàudia Ferrer-Aumatell, Grégoire Mercier,
Molecular systems biologyno. 4 (2024): 374-402
Endocrinologyno. 6 (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Protein & cellno. 2 (2023): 123-136
BMC Biologyno. 1 (2023): 1-23
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