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We have two interconnected biomedical research themes. In the first theme, we are studying how cells make blood vessels. We are investigating how cells are able to lay down an intricate and stretchy structural framework that is made up of many different molecules, and how this elastic ‘matrix’ controls blood vessel function. This research focuses especially on a large structural molecule called "fibrillin" which, once outside cells, builds very long thin ‘microfibril’ structures. Bundles of these microfibrils then form the template for an important elastic protein called ‘elastin’. In the second theme, we are studying a type of adult stem cell called “mesenchymal stem cell” that occurs near blood vessels. These cells have great potential for tissue regeneration, both because they are able to become like cells from many tissues (including blood vessels, cartilage, bone and nerves), and because they produce ‘factors’ that limit inflammation after injury.
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The Journal of biological chemistryno. 16 (2020): 5278-5291
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