He currently works mostly on knowledge discovery technologies and their application to biomedicine. He has also done, in the earlier part of his career, significant research in database query language theory and finite model theory, as well as significant development work in broad-scale data integration systems. Limsoon has written about 300 research papers, some of which are among the best cited of their respective fields. Limsoon is a Fellow of the ACM, named in 2013 for his contributions to database theory and computational biology. Some of his other awards include the 2003 FEER Asian Innovation Gold Award for his work on treatment optimization of childhood leukemias, the 2006 Singapore Youth Award Medal of Commendation for his sustained contributions to science and technology, and the ICDT 2014 Test of Time Award for his work on naturally embedded query languages. He was also conferred, in 2014, a Public Administration Medal (Bronze) by the Singapore Government for outstanding efficiency, competence, and industry. He serves/served on the editorial boards of Journal of Bioinformatics and Computational Biology, Bioinformatics, Biology Direct, Drug Discovery Today, IEEE/ACM Transactions on Computational Biology and Bioinformatics, Genomics Proteomics & Bioinformatics, Journal of Biomedical Semantics, Methods, Scientific Reports, Information Systems, and IEEE Transactions on Big Data.