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个人简介
My research aims at understanding the molecular basis for biological function in two main areas. The first involves understanding how amino acid sequence controls protein structural dynamics using pressure perturbation combined with state-of-the-art biophysical techniques. This is important information for protein design strategies for bio-pharmaceutics and for bio-engineering applications, as well as for understanding the evolution of protein sequences and life in extreme environments. The second area of research that I pursue involves characterizing, quantitatively, the protein interactions implicated in the regulation of gene expression. Currently we are trying to understand the links between cell growth and division in the model organism, budding yeast by applying advanced quantitative microscopy approaches. Understanding what drives cells to divide is important for understanding and developing therapeutic strategies for the treatment of many diseases, including cancer.
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Pooja Goswami,Abhishek Ghimire, Carleton Coffin,Jing Cheng, Jasmin Coulombe-Huntington,Ghada Ghazal,Yogitha Thattikota,Mike Tyers, Sylvain Tollis,Catherine Royer
biorxiv(2024)
Proceedings of the National Academy of Sciences of the United States of Americano. 26 (2023)
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Proceedings of the National Academy of Sciences of the United States of Americano. 26 (2023)
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Luca Mazzei,Rebecca Greene-Cramer,Khushboo Bafna, Aleksandar Jovanovic, Anna De Falco,Thomas B. Acton,Catherine Ann Royer,Stefano Ciurli,Gaetano T. Montelione
STAR Protocolsno. 2 (2023): 102326-102326
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