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Building on my earliest observations of ligand binding to folded proteins, I became fascinated by the balance of interactions that enable proteins and their complexes to survive in the gas phase. This has guided my research over the years and prompted many of my current questions and future directions.
The central tenet of our research is that native mass spectrometry (MS), a technique which enables interactions of proteins to be maintained in the gas phase, can provide unparalleled information on the structure, binding partners and dynamics of proteins, complementing other biophysical approaches yet a powerful tool in its own right. Particularly exciting is, I believe, the agility with which native MS can be adapted and applied to the research challenges of our time. Our overall goal is to continue to develop and advance our native MS methods for application to a range of fundamental and applied research goals.
The central tenet of our research is that native mass spectrometry (MS), a technique which enables interactions of proteins to be maintained in the gas phase, can provide unparalleled information on the structure, binding partners and dynamics of proteins, complementing other biophysical approaches yet a powerful tool in its own right. Particularly exciting is, I believe, the agility with which native MS can be adapted and applied to the research challenges of our time. Our overall goal is to continue to develop and advance our native MS methods for application to a range of fundamental and applied research goals.
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Zihao Wang, Guodong Cao,Miranda P Collier,Xingyu Qiu,Sophie Broadway-Stringer,Dominik Saman, Jediael ZY NG, Navoneel Sen,Amar J Azad, Charlotte Hooper,Johannes Zimmermann,Michael McDonough,
biorxiv(2024)
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Science advancesno. 7 (2024): eadl4628-eadl4628
Yan Yan, Jun Xiao,Fengtao Huang,Wei Xian,Bingbing Yu,Rui Cheng,Hui Wu,Xueling Lu,Xionglue Wang, Wenjing Huang, Jing Li,Greater Kayode Oyejobi,
John William Young,Emanuel Pfitzner, Raman van Wee, Carla Kirschbaum,Philipp Kukura,Carol V. Robinson
ISCIENCEno. 2 (2024): 108785-108785
Nanami Senoo, Dinesh Chinthapalli,Matthew Baile, Vinaya Golla,Bodhisattwa Saha,Nathan Alder,Eric May,Carol Robinson,Steven Claypool
Journal of Biological Chemistryno. 3 (2024)
Gang Du, Liam B Healy,Liron David,Caitlin Walker,Tarick J El-Baba,Corinne A Lutomski,Byoungsook Goh, Bowen Gu,Xiong Pi,Pascal Devant,Pietro Fontana,Ying Dong,
JOURNAL OF THE AMERICAN CHEMICAL SOCIETYno. 10 (2024): 7007-7017
Sophie A S Lawrence, Carla Kirschbaum, Jack L Bennett,Corinne A Lutomski,Tarick J El-Baba,Carol V Robinson
ACS chemical biology (2024)
Abraham Olusegun Oluwole, Neha Kalmankar, Michela Guida, Jack L Bennett,Giovanna Poce,Jani R Bolla,Carol V Robinson
biorxiv(2024)
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