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Our research encompasses two major areas: Understanding the mechanism of protein import into mitochondria and determining the process by which defects in mitochondrial protein translocation lead to disease.
A basic question in cell biology is the mechanism by which a protein reaches its correct location within the cell. Of all the organelles in a mammalian cell, the mitochondrion is the most complex because two membranes must be crossed. In addition to the metabolic role, the mitochondria is a key player in many cellular processes including apoptosis, metal ion homeostasis and aging. My specific interests lie in mitochondrial biogenesis, particularly the mechanism by which proteins are imported into the mitochondrial inner membrane.
A basic question in cell biology is the mechanism by which a protein reaches its correct location within the cell. Of all the organelles in a mammalian cell, the mitochondrion is the most complex because two membranes must be crossed. In addition to the metabolic role, the mitochondria is a key player in many cellular processes including apoptosis, metal ion homeostasis and aging. My specific interests lie in mitochondrial biogenesis, particularly the mechanism by which proteins are imported into the mitochondrial inner membrane.
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论文共 128 篇作者统计合作学者相似作者
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Journal of Biological Chemistryno. 3 (2023): 103860-S456
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Mingqi Han,Eric A. Bushong,Mayuko Segawa,Alexandre Tiard,Alex Wong, Morgan R. Brady,Milica Momcilovic,Dane M. Wolf, Ralph Zhang,Anton Petcherski,Matthew Madany,Shili Xu,
Sean Atamdede,Jordan Tibbs,Janos Steffen,David Austin,Nicole Zagon, Ryan Howe,Robert Damoiseaux, Alex van der Bliek,Carla Koehler
Journal of Biological Chemistryno. 3 (2023): 103957-S513
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Eric Torres,Colin Douglas,Robert Damoiseaux, Jenny Ngo, Kayla Frank,James Wohlschlegel,Alexander van der Bliek,Carla Koehler
SSRN Electronic Journal (2022)
Danyun Zhang,Owen R Dailey,Daniel J Simon, Kamilah Roca-Datzer,Yasaman Jami-Alahmadi, Mikayla S Hennen, James A Wohlschlegel,Carla M Koehler,Deepa V Dabir
Mingqi Han,Milica Momcilovic,Eric Bushong,Linsey Stiles,Orian Shirihai,Carla Koehler,Saman Sadeghi, Mark Ellisman, David B. Shackelford
Adam D Langenbacher,Hirohito Shimizu, Welkin Hsu,Yali Zhao, Alexandria Borges,Carla Koehler,Jau-Nian Chen
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