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General Interests
Regulation of Vascular Tone and Adrenal Steroidogenesis by Endothelial Factors
Research Interests
Endothelial cells are the vascular cells that line the lumen of blood vessels; they are in contact with smooth muscle cells on one side and circulating blood cells on the other. Endothelium modulates vascular tone and provides a nonthrombogenic surface for blood vessels. These actions are mediated through the release of soluble mediators and some of these mediators are metabolites of arachidonic acid. Arachidonic acid undergoes a variety of oxidation reactions to yield several families of biologically active lipids called eicosanoids. The principal enzymatic pathways of arachidonic acid metabolism include cyclooxygenase, lipoxygenases and cytochrome P450 epoxygenase. The products of these pathways include the prostaglandins, thromboxane, leukotrienes and others. Eicosanoids act as local hormones to regulate cell function and to communicate among cells. Endothelial cells, for example, synthesize prostacyclin from arachidonic acid. It causes relaxation of vascular smooth muscle and inhibits platelet aggregation. Research in our laboratory involves the isolation and identification of new metabolites of arachidonic acid and other endothelial mediators of vascular function. Once identified, the biological activities of the mediators are determined, their mechanism of action examined and the regulation of their synthesis investigated. These studies are important to our understanding of the causes of hypertension and ischemic heart disease and provide insights into new therapies.
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Khawaja M. Talha,John G. Winscott, Vishal Patel,Kellan E. Ashley, Michael McMullan,Alejandro Lemor,William Campbell,Gabriel A. Hernandez
CIRCULATIONno. 1 (2023): 36-38
Frank Han,Sara Kiparizoska,William Campbell, Camille Richards,Brian Kogon,Marlene Holloway, Connie Watson,Edmund K Kerut,Michael McMullan
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