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个人简介
A physicist by training, Dr. Califano has taken innovative, systematic approaches to identify the molecular factors that lead to cancer progression and to the emergence of drug resistance at the single-cell level. Directing the conversation about cancer research away from focusing solely on gene mutations, Dr. Califano examines the complex and tumor-specific molecular interaction networks that determine cancer cell behavior. Using information theoretic approaches, analysis of these networks can precisely pinpoint master regulator proteins that are mechanistically responsible for supporting tumorigenesis and for implementing tumor cell homeostasis. Dr. Califano and his lab have shown that master regulators represent critical drivers and tumor dependencies, despite the fact that they are rarely mutated or differentially expressed, thus establishing them as a bona fide new class of therapeutic targets.
研究兴趣
论文共 317 篇作者统计合作学者相似作者
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Marie C. Hasselluhn,Dafydd Thomas,Lukas Vlahos,Alvaro Curiel-Garcia, Amanda R. Decker-Farrell, Tanner C. Dalton, Stephen A. Sastra,Carmine F. Palermo,Andrea Califano,Kenneth P. Olive
Cancer Researchno. 6_Supplement (2024): 1596-1596
Alvaro Curiel-Garcia,Lorenzo Tomassoni, Tanner C. Dalton, Amanda R. Decker-Farrell,Carmine F. Palermo, Daniel R. Ross, Stephen A. Sastra, Urszula N. Wasko, Isabel M. Goncalves, Prabhot Mundi,Basil S. Bakir,Rachael A. Safyan,
Cancer Researchno. 6_Supplement (2024): 934-934
Ester Calvo Fernandez,Lorenzo Tomassoni,Xu Zhang,Aleksandar Obradovic,Pasquale Laise,Aaron T. Griffin,Lukas Vlahos,Junqiang Wang,Hanna E. Minns, Diana V. Morales, Christian Simmons, Matthew Gallito,
Cancer Researchno. 6_Supplement (2024): 5460-5460
Luca Zanella, Alexander L. Wang, Zizhao J. Lin,Lukas J. Vlahos, Miquel Anglada Girotto, Aziz Zafar,Andrea Califano,Alessandro Vasciaveo
Cancer Researchno. 6_Supplement (2024): 7410-7410
Cancer Researchno. 6_Supplement (2024): 2757-2757
Filemon S. Dela Cruz,Prabhjot S. Mundi, Armaan Siddiquee, Kristina Guillan, Daoqi You, Glorymar Ibanez Sanchez, Andoyo Ndengu,Andrea Califano, Andrew L. Kung
Cancer Researchno. 6_Supplement (2024): 6227-6227
crossref(2024)
CANCER RESEARCHno. 2 (2024)
Cancer Researchno. 6_Supplement (2024): 6516-6516
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