Research Summary
Main interest is to bridge the basic study, translational study and clinical study based on an immunological foundation. The main research fields are listed below:

Basic Studies: Immune mechanisms of immune regulation: using mice model to explore the suppression mechanisms of different regulatory immune cells, including regulatory T cells, tolerogenic dendritic cells; tumor-associated macrophage and MDSC
A. Immune regulation in tumor immunotherapy: using mice model to develop strategies of tumor immunotherapy, especially to block the inhibition effect of immune regulation.
B. Immune regulation in acute liver injury: using mice model to explore the immune derangement in acute liver injury and to develop possible treatment strategies
Translational Studies: Immune regulation in chronic viral hepatitis, liver cirrhosis, acute liver failure and cancer: using human studies to understand the impact of immune regulation on the disease progression and treatment outcome. The aim is to develop effective immune therapy and to develop useful immunometer for predict the disease progression.
Clinical studies: Disease characteristics and treatment responses for chronic hepatitis C, chronic hepatitis B, liver cirrhosis and hepatoma. An immunological concept is the main underlying reasoning to approach these diseases.