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个人简介
My research focuses on acute myeloid leukaemia (AML), the commonest aggressive leukaemia in adults. I am particularly interested in the immune control of AML following allogeneic stem cell transplantation. The curative effect of stem cell transplantation relies on alloreactivity of donor T cells against cancer cells, which is known as Graft-versus-Leukaemia (GvL). Remarkably, despite being administered for over 50 years, our understanding of the AML antigens that trigger and sustain a donor T cell response after allo-SCT is very limited. I use a combination of next-generation sequencing, bioinformatic analysis and immunology assays to characterise GvL responses in AML.
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The hematologistno. 4 (2023)
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Hannah Higgins,Nick Andrews,Julia Stowe,Gayatri Amirthalingam,Mary Ramsay, Gurpreet Bahra, Anthony Hackett,Karen A Breen,Michael Desborough,Dalia Khan,Heather Leary,Connor Sweeney,
Cancer cellno. 5 (2020): 690-704.e8
C Nerlov, C Di Genua,S Valletta,M Buono,B Stoilova,C Sweeney,A Rodriguez-Meira, A Grover,Y Meng, R Beveridge, Z Aboukhalil,D Karamitros,
Oxford Textbook of Cancer Biologypp.283-300, (2019)
Desborough Mjr., K S Colman, B W Prick, J J Duvekot,C Sweeney,Ayodele Odutayo,Vipul Jairath,Carolyn Doree,Marialena Trivella,Sally Hopewell,Lise J Estcourt,Simon J Stanworth
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