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个人简介
Research in the Serhan laboratory focuses on structural elucidation of bioactive small molecules that activate the resolution of acute inflammation. Our overall mission is “To identify novel mediators, pathways, and cellular targets critical in promoting resolution of inflammation and reperfusion tissue injury and their relation to human disease.” Our studies currently focus on structural elucidation of novel molecules and pathways that serve as pro-resolving and/or endogenous anti-inflammatory chemical signals. We elucidated several new families of lipid-derived, local-acting chemical mediators, coined the Resolvins and Protectins, and most recently Maresins, that stimulate resolution of inflammatory responses. We also designed novel therapeutic approaches using these structures as biotemplates. New therapeutic approaches built with the knowledge of these signaling pathways could be more potent, selective and better tolerated since they are based on structures naturally evolved in these processes. Several of these new designer therapeutics have already been shown to be effective in human disease.
研究兴趣
论文共 1017 篇作者统计合作学者相似作者
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Megan L Sulciner,Charles N Serhan,Molly M Gilligan, Dayna K Mudge,Jaimie Chang,Allison Gartung, Kristen A Lehner,Diane R Bielenberg, Birgitta Schmidt,Jesmond Dalli, Emily R Greene, Yael Gus-Brautbar,
The Journal of experimental medicineno. 3 (2024)
Nature Reviews Cardiologypp.1-16, (2024)
Katherine Quinlivan,Haixia Yang,Diane R. Bielenberg,Susanne I. Wells,Charles N. Serhan,Dipak Panigrahy
Cancer Researchno. 6_Supplement (2024): 1416-1416
Hong Yong Peh, Thayse R. Brueggemann,Melody G. Duvall,Robert Nshimiyimana,Julie Nijmeh, Maria A. Cinelli,Elliot Israel,Charles N. Serhan,Bruce D. Levy
Jacqueline Capuano, Kimberly Vasquez, Katherine Quinlivan, Rachel Bayer, Sarina Virani, Michael Gillespie,Mark Kieran,Charles Serhan,Diane Bielenberg,Dipak Panigrahy
Cancer Researchno. 6_Supplement (2024): 7458-7458
Sarina A. Virani, Michael Gillespie,Haixia Yang,Diane R. Bielenberg,Mark W. Kieran,Sui Huang,Charles N. Serhan,Dipak Panigrahy
Cancer Researchno. 6_Supplement (2024): 6817-6817
BRITISH JOURNAL OF PHARMACOLOGY (2023): S23-S144
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