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Hepatitis B virus (HBV) also causes cirrhosis and liver cancer, and Rice’s group is now applying the human liver mice, as well as new in vitro culture methods, to study HBV, which is often refractory to curative treatment due to the virus’s highly stable covalently closed circular DNA genome (cccDNA). The work is revealing new strategies to target cccDNA and other critical HBV lifecycle steps. Rice’s group continues to develop new technologies, such as 3D and induced pluripotent stem cell-derived cultures, to study HCV, HBV, and other viruses. They are also using the human liver mice to study the roles of diet and human genetics on the development of non-infectious causes of liver disease.
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JOURNAL OF VIROLOGY (2024)
Cancer Researchno. 6_Supplement (2024): 6906-6906
Angela L Rasmussen, Gigi K Gronvall,Anice C Lowen,Felicia Goodrum,James Alwine,Kristian G Andersen,Simon J Anthony,Joel Baines, Arinjay Banerjee,Andrew J Broadbent, Christopher B Brooke,Samuel K Campos,
Journal of virologyno. 3 (2024): e0007424-e0007424
Alex Rialdi,Mary Duffy,Alex P. Scopton, Frank Fonseca,Julia Nanyi Zhao,Megan Schwarz,Pedro Molina-Sanchez,Slim Mzoughi, Elisa Arceci,Jordi Abril-Fornaguera, Austin Meadows,Marina Ruiz de Galarreta,
Kimberly F. Glassman,Joan S. Brugge, Anthony F. Purchio, Laura T. Kakach,Thomas R. Fuerst, Robert M. Woods,C. Kendall Stover,Srinivas K. Chunduru,Jeffrey R. Hincks,Mark A. McKinlay, Claude H. Nash,Daniel C. Pevear,
Journal of virologyno. 1 (2023): e0164322-e0164322
Clinical infectious diseases : an official publication of the Infectious Diseases Society of Americano. Supplement_3 (2023): S257-S261
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