基本信息
浏览量:218
职业迁徙
个人简介
Her group was among the first to demonstrate impressive activity of CD19-CAR in pediatric leukemia (Lancet 2015), developed a CD22-CAR that is the only active salvage therapy for CAR19 resistant B cell malignancies (Nat Med 2018, J Clin Onc 2020, Blood 2021), demonstrated preclinical activity of GD2 targeting CARs for pediatric diffuse intrinsic pontine glioma (Nat Med 2018), demonstrated superiority of regional CNS delivery of CAR T cells for brain tumors (Nat Med 2020) and demonstrated impressive clinical activity of GD2-CAR T cells in this disease (NCT04196413), which is among the first to demonstrate significant and consistent activity of CAR T cells in solid cancers (Nature 2022). Her group identified T cell exhaustion as a major feature CAR T cell potency (Nat Med 2015), created the first exhaustion-resistance (Nature 2019) and exhaustion-reversal platforms (Science 2021) and developed a best-in-class regulatable “remote-controlled” CAR T cell platform (Cell, 2022). She serves in numerous national leadership positions, including Co-PI of a Pediatric Immunotherapy Discovery and Development Network U54 grant, and co-Leader of the St. Baldrick’s-StandUp2Cancer Pediatric Dream Team. She has received numerous awards, including election as a fellow of the AACR Academy, the Smalley Award for outstanding contributions to cancer immunotherapy from the Society for the Immunotherapy of Cancer, the AACR-St.Baldrick’s Distinguished Achievement Award for Pediatric Cancer Research, and the Nobility in Science Award from the Sarcoma Foundation of America. She has published over 250 manuscripts and her h-index in August 2022 according to google scholar is 96 and founded 3 biotech companies. Crystal is Board Certified in Pediatrics, Pediatric Hematology-Oncology and Internal Medicine.
研究兴趣
论文共 604 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Alexander E. Doan,Katherine P. Mueller, Andy Y. Chen, Geoffrey T. Rouin,Yingshi Chen,Bence Daniel,John Lattin, Martina Markovska, Brett Mozarsky, Jose Arias-Umana,Robert Hapke,In-Young Jung,
NATURE (2024)
CANCER CELLno. 1 (2024): 35-51.e8
Liora M. Schultz,Nikeshan Jeyakumar,Anne Marijn Kramer,Bita Sahaf, Hrishi Srinagesh,Parveen Shiraz, Neha Agarwal,Mark Hamilton,Courtney Erickson,Ashley Jacobs,Jennifer Moon,Christina Baggott,
Leukemiapp.1-6, (2024)
Naturepp.1-9, (2024)
Victor Tieu,Elena Sotillo, Jeremy R. Bjelajac, Crystal Chen,Meena Malipatlolla,Justin A. Guerrero, Peng Xu, Patrick J. Quinn,Chris Fisher,Dorota Klysz,Crystal L. Mackall,Lei S. Qi
Cellno. 5 (2024): 1278-1295.e20
Janaki Manoja Vinnakota,Francesca Biavasco,Marius Schwabenland,Chintan Chhatbar,Rachael C Adams,Daniel Erny,Sandra Duquesne,Nadia El Khawanky,Dominik Schmidt, Viktor Fetsch, Alexander Zähringer,Henrike Salié,
Nature cancerpp.1-23, (2024)
Nature Medicineno. 2 (2024): 338-341
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn