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个人简介
Research in the Schofield group aims to contribute to a chemical understanding of biological systems, where possible of medicinal or agricultural importance. We have a particular interest in metallo-enzymes that are included in antibiotic biosynthesis and resistance as well as in human physiology. The iron and zinc dependent enzymes we study are of intrinsic chemical interest because they can catalyse reactions presently impossible for synthetic chemistry. Some of them also play roles in human physiology and disease, e.g. in enabling us to respond to limiting oxygen availability and to repair damage to our DNA. We are presently interested in understanding the details of how environmental factors regulate gene expression, with a particular focus on oxygen regulated processes. We are a highly collaborative group, often working with researchers in academia and industry. A major current focus is working in the Ineos Oxford Institute for Antimicrobial Resistance to combat antibacterial resistance both in human and farming applications.
研究兴趣
论文共 972 篇作者统计合作学者相似作者
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Anandhu Krishnan,Sodiq O. Waheed,Ann Varghese, Fathima Hameed Cherilakkudy,Christopher J. Schofield,Tatyana G. Karabencheva-Christova
Chemical Scienceno. 10 (2024): 3466-3484
Zihao Wang, Guodong Cao,Miranda P Collier,Xingyu Qiu,Sophie Broadway-Stringer,Dominik Saman, Jediael ZY NG, Navoneel Sen,Amar J Azad, Charlotte Hooper,Johannes Zimmermann,Michael McDonough,
biorxiv(2024)
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Takashi Miura,Tika R Malla,Lennart Brewitz,Anthony Tumber,Eidarus Salah, Kang Ju Lee,Naohiro Terasaka,C David Owen,Claire Strain-Damerell,Petra Lukacik,Martin A Walsh,Akane Kawamura,
Bulletin of the Chemical Society of Japan (2024)
Hannah Lawson,James P. Holt-Martyn,Vilma Dembitz,Yuka Kabayama, Lydia M. Wang, Aarushi Bellani, Samanpreet Atwal, Nadia Saffoon,Jozef Durko, Louie N. van de Lagemaat, Azzura L. De Pace,Anthony Tumber,
Nature Cancerpp.1-22, (2024)
Tobias John, Nadia Saffoon,John Walsby-Tickle,Svenja S. Hester,Felix A. Dingler, Christopher L. Millington,James S. O. McCullagh,Ketan J. Patel,Richard J. Hopkinson,Christopher J. Schofield
CHEMICAL SCIENCEno. 7 (2024): 2509-2517
CURRENT OPINION IN CHEMICAL BIOLOGY (2024): 102428-102428
Anandhu Krishnan,Sodiq O. Waheed,Ann Varghese, Fathima Hameed Cherilakkudy,Christopher J. Schofield,Tatyana G. Karabencheva-Christova
Anandhu Krishnan,Sodiq O Waheed,Ann Varghese, Fathima Hameed Cherilakkudy,Christopher J Schofield,Tatyana G Karabencheva-Christova
Chemical scienceno. 10 (2024): 3466-3484
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