The focus of my research has mainly been early origins of psychological and mental disorders, testing the association between pre- and perinatal effects with development of psychiatric disorders (schizophrenia, affective psychosis, reactive psychosis, post-partum psychosis, anorexia nervosa, ADHD and autism) and high-risk paradigms with children at high risk for schizophrenia and bipolar disorder. In samples of twins, siblings, half-siblings, family pairs and high-risk offspring I have studied fetal environmental hazards, maternal life style/social disadvantage, paternal age effects and genetic liability using designs that permits simultaneously evaluation of maternal and paternal genetic and environmental influences. During 2008 through 2016, I was responsible for DNA collection of 5, 500 patients with schizophrenia, 5, 000 bipolar patients, 1300 cases with infantile autism and their parents and grandparents, 380 schizophrenia and bipolar twin pairs and 7, 500 healthy controls on a population basis.