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He is the current chair of the Gynaecological Cancer Intergroup (GCIG) Translational Committee and is a member of the Scottish Medicines Consortium and the German Cancer Aid Scientific Review Committee. He previously sat on the Scientific Evaluation Committee, Institut National du Cancer in France, the Cancer Research UK Experimental Medicine Expert Review Panel as well as the Commission on Human Medicines Oncology and Haematology Expert Advisory Group.
Charlie is active in ovarian cancer clinical trials. He was UK lead for the SOLO1 trial which led to the first line licence for olaparib in BRCA mutant ovarian cancer and for the recently reported GOG281/LOGS trial of trametinib which is the first ever positive randomised controlled trial in low grade serous ovarian cancer. He sits on the trial management group of a number of UK ovarian cancer trials including ICON9, CENTURION and PEACOCC. He provides leadership on the translational aspects of these studies as well as commercial studies such as PISARRO and PRO-105.
Professor Gourley’s translational research focuses on genomic characterisation of ovarian cancer in order to facilitate the discovery of biomarkers of ovarian cancer drug sensitivity and resistance. Current priorities include whole genome sequencing of ovarian cancer tumours from across Scotland in order to improve patient selection for PARP inhibitors and exomic sequencing of low grade serous ovarian cancers from patients recruited into the GOG281/LOGS study in order to improve patient selection for MEK inhibition. His lab group includes two postdoctoral fellows, one senior scientist, three PhD students, a data manager, a tissue collector/processor and a scientific officer.
Charlie is active in ovarian cancer clinical trials. He was UK lead for the SOLO1 trial which led to the first line licence for olaparib in BRCA mutant ovarian cancer and for the recently reported GOG281/LOGS trial of trametinib which is the first ever positive randomised controlled trial in low grade serous ovarian cancer. He sits on the trial management group of a number of UK ovarian cancer trials including ICON9, CENTURION and PEACOCC. He provides leadership on the translational aspects of these studies as well as commercial studies such as PISARRO and PRO-105.
Professor Gourley’s translational research focuses on genomic characterisation of ovarian cancer in order to facilitate the discovery of biomarkers of ovarian cancer drug sensitivity and resistance. Current priorities include whole genome sequencing of ovarian cancer tumours from across Scotland in order to improve patient selection for PARP inhibitors and exomic sequencing of low grade serous ovarian cancers from patients recruited into the GOG281/LOGS study in order to improve patient selection for MEK inhibition. His lab group includes two postdoctoral fellows, one senior scientist, three PhD students, a data manager, a tissue collector/processor and a scientific officer.
研究兴趣
论文共 324 篇作者统计合作学者相似作者
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Lorna J Stillie,Ailith Ewing,Alison Meynert,John P Thomson,Michael Churchman,C Simon Herrington,Patricia Roxburgh,Gareth J Inman,Robert L Hollis, Colin A Semple,Charlie Gourley
Poster and E-Posters (2024)
Ailith Ewing,Alison Meynert, Ryan Silk,Stuart Aitken, Devin P Bendixsen,Michael Churchman, Stuart L Brown, Alhafidz Hamdan, Joanne Mattocks,Graeme R Grimes,Tracy Ballinger,Robert L Hollis,
biorxiv(2024)
Lena Rai, Antonella Ravaggi, Eliana Bignotti, Robb Hollis, Joel Nulsen,Leticia Campo,Alistair Easton,Mara Artibani, Mike Churchman, Federico Ferrari,Christopher Yau,Charlie Gourley,
Cancer Researchno. 6_Supplement (2024): 2491-2491
Ranjit Manchanda,Li Sun,Monika Sobocan,Isabel V. Rodriguez,Xia Wei,Ashwin Kalra,Samuel Oxley,Michail Sideris, Caitlin T. Fierheller,Robert D. Morgan,Dhivya Chandrasekaran, Kelly Rust,
Journal of the National Comprehensive Cancer Networkpp.1-9, (2024)
Robert L. Hollis, Richard Elliott,John C. Dawson,Narthana Ilenkovan, Rosie M. Matthews,Lorna J. Stillie,Ailsa J. Oswald,Hannah Kim,Marta Llaurado Fernandez,Michael Churchman, Joanna M. Porter,Patricia Roxburgh,
Gynecologic Oncology (2024): 42-52
Euan A. Stronach, Albandri Alfraidi,Nona Rama,Christoph Datler,James B. Studd,Roshan Agarwal, Tankut G. Guney,Charlie Gourley,Bryan T. Hennessy,Gordon B. Mills,Antonello Mai,Robert Brown,
crossref(2023)
Charlie Gourley, Adam J.W. Paige,Karen J. Taylor,Carol Ward, Barbara Kuske,Jieqing Zhang,Mingjun Sun,Szymon Janczar,David J. Harrison,Morwenna Muir, John F. Smyth,Hani Gabra
crossref(2023)
S. Banerjee,A. Leary,J.R. Stewart, M. Dewan,S. Lheureux,A.R. Clamp, I.L. Ray-Coquard, F. Selle,C. Gourley,R.M. Glasspool, R. Bowen,A. Attygalle,
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