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The lab focuses on exploring how the trafficking of receptor tyrosine kinases (RTKs) from and to the plasma membrane can elicit specific cellular responses. We use a highly multidisciplinary approach named ‘functional proteomics’, which integrates quantitative Mass Spectrometry (MS)-based proteomics, bioinformatics analysis, functional assays and imaging techniques. Our research aims at uncovering the molecular mechanisms underlying the intracellular trafficking of RTKs, resultant signaling specificity, and downstream outputs during development and cancer progression. The final goal hereby is to identify and characterize proteins with key roles in RTK signaling and trafficking that can be targeted for intervention in human diseases.
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论文共 56 篇作者统计合作学者相似作者
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FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2024): 1348056-1348056
Masato Murakami,Chiara Francavilla, Ilaria Torselli,Monica Corada,Luigi Maddaluno,Antonio Sica, Gianluca Matteoli,Iliyan Dimitrov Iliev,Alberto Mantovani,Maria Rescigno,Ugo Cavallaro,Elisabetta Dejana
crossref(2023)
crossref(2023)
crossref(2023)
MOLECULAR & CELLULAR PROTEOMICSno. 8 (2023): 100594-100594
Joseph Parsons,Hannah Harrison, Tom Kedward,Paul Fullwood, Sara Cabral,Katherine Spence, Danielle Barden, Jennifer Haworth,Joanne Watson, Kalliopi Tsafou, Caron Behan,Nisha Ali,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Masato Murakami,Chiara Francavilla, Ilaria Torselli,Monica Corada,Luigi Maddaluno,Antonio Sica, Gianluca Matteoli,Iliyan Dimitrov Iliev,Alberto Mantovani,Maria Rescigno,Ugo Cavallaro,Elisabetta Dejana
crossref(2023)
Nature Structural & Molecular Biologyno. 11 (2023): 1609-1611
Masato Murakami,Chiara Francavilla, Ilaria Torselli,Monica Corada,Luigi Maddaluno,Antonio Sica, Gianluca Matteoli,Iliyan Dimitrov Iliev,Alberto Mantovani,Maria Rescigno,Ugo Cavallaro,Elisabetta Dejana
crossref(2023)
Chiara Francavilla, Ciara S O'Brien
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