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We study the neural mechanisms that give particular sensory stimuli emotional value, leading to emotional behavior. Using the primate visual system as an experimental platform, our basic approach is to conduct neurophysiological experiments in rhesus monkeys performing a variety of tasks involving emotional learning. We generally use conditioning techniques to give otherwise neutral stimuli emotional significance.
We are investigating the physiological responses of amygdala neurons during emotional learning. The amygdala is a limbic brain structure likely to be critical to the process of associating sensory stimuli with emotional values. Simultaneously, we employ quantitative measurements of emotional learning and behavior in the monkey. We are testing the hypothesis that modulations in amygdala neural activity are correlated with the monkeys' emotional learning, behavior, and decision making.
Future studies are planned in three general directions. First, we plan to study how orbitofrontal cortex contributes to emotional learning and behavior on the tasks we employ. Parts of orbitofrontal cortex are intimately connected to the amygdala, and our goal is to understand the distinct processing in these brain areas. Second, we plan to investigate how stimuli in other sensory modalities become associated with emotional value in the amygdala. The amygdala receives input from multiple sensory modalities, and therefore representations of emotional value in the amygdala may exist across sensory modalities, perhaps even in the same cells. Finally, we plan to use pharmacological manipulations to try to understand the critical synaptic mechanisms underlying emotional learning. These experiments may deepen our understanding of psychopharmacology by linking synaptic mechanisms to both neurophysiology and to emotional behavior.
We are investigating the physiological responses of amygdala neurons during emotional learning. The amygdala is a limbic brain structure likely to be critical to the process of associating sensory stimuli with emotional values. Simultaneously, we employ quantitative measurements of emotional learning and behavior in the monkey. We are testing the hypothesis that modulations in amygdala neural activity are correlated with the monkeys' emotional learning, behavior, and decision making.
Future studies are planned in three general directions. First, we plan to study how orbitofrontal cortex contributes to emotional learning and behavior on the tasks we employ. Parts of orbitofrontal cortex are intimately connected to the amygdala, and our goal is to understand the distinct processing in these brain areas. Second, we plan to investigate how stimuli in other sensory modalities become associated with emotional value in the amygdala. The amygdala receives input from multiple sensory modalities, and therefore representations of emotional value in the amygdala may exist across sensory modalities, perhaps even in the same cells. Finally, we plan to use pharmacological manipulations to try to understand the critical synaptic mechanisms underlying emotional learning. These experiments may deepen our understanding of psychopharmacology by linking synaptic mechanisms to both neurophysiology and to emotional behavior.
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user-5f1696ff4c775ed682f5929f(2018)
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