Chung-Wai Chow
副教授
Centre for Global Health
Dalla Lana School of Public Health, University of Toronto;Occupational & Environmental Health Division, Dalla Lana School of Public Health, University of Toronto;Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto;Toronto General Hospital Research Institute
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个人简介
There are two theme in my research group:
The first theme is focused on understanding the effects of environmental air pollution on cardiorespiratory health. Current projects include:
1. studies in the lung transplant population to evaluate uptake of traffic-related air pollutants in the lung, and the correlation of these levels with ambient air pollutant and outcomes following transplantation
2. real-time exposure of ambient air pollutants and vehicular exhaust, and their effect on respiratory and cardiac function in vivo using different animal models of chronic inflammatory lung diseases, ventilator-based evaluation of lung function and cardiac telemetry
3. use of ex vivo lung slices to study the physiological responses, and in vitro cell culture models to identify the cellular pathways that regulate response to different components of air pollutants; these project using real time live imaging and cutting edge cellular molecular biology techniques
The second theme focuses on the role of Syk in modulating airway inflammation, tissue injury and airway remodeling, a common feature observed in chronic lung diseases such as asthma, chronic obstructive lung disease and chronic lung graft rejection following transplantation. Research is carried out in vitro using mono- and co-cultures of airway epithelial and airway smooth muscle cells, and ex vivo and in vivo using several animal models of allergen-induced asthma and lung transplantation.
The first theme is focused on understanding the effects of environmental air pollution on cardiorespiratory health. Current projects include:
1. studies in the lung transplant population to evaluate uptake of traffic-related air pollutants in the lung, and the correlation of these levels with ambient air pollutant and outcomes following transplantation
2. real-time exposure of ambient air pollutants and vehicular exhaust, and their effect on respiratory and cardiac function in vivo using different animal models of chronic inflammatory lung diseases, ventilator-based evaluation of lung function and cardiac telemetry
3. use of ex vivo lung slices to study the physiological responses, and in vitro cell culture models to identify the cellular pathways that regulate response to different components of air pollutants; these project using real time live imaging and cutting edge cellular molecular biology techniques
The second theme focuses on the role of Syk in modulating airway inflammation, tissue injury and airway remodeling, a common feature observed in chronic lung diseases such as asthma, chronic obstructive lung disease and chronic lung graft rejection following transplantation. Research is carried out in vitro using mono- and co-cultures of airway epithelial and airway smooth muscle cells, and ex vivo and in vivo using several animal models of allergen-induced asthma and lung transplantation.
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Amirashkan Askari, Xing Wang, Rachel Ortiz,Patricia Di Ciano,Ahmed N. Hassan,Sergio Rueda,Chung-Wai Chow,Arthur W.H. Chan
Indoor Environmentspp.100006, (2024)
Joyce K.Y. Wu, Jessica Jia-Ni Xu,Anastasiia Vasileva, Cynthia Nohra,Matthew Binnie,Shane Shapera,Jolene H. Fisher,Clodagh M. Ryan,Micheal McInnis,Zoltán Hantos,Chung-Wai Chow
Respiratory Medicine Case Reports (2024): 102016-102016
Natalia Belousova,Ella Huszti,Qixuan Li, Anastasiia Vasileva,Rasheed Ghany, Ramy Gabarin, Moustapha El Sanharawi,Clement Picard,David Hwang,Liran Levy,Shaf Keshavjee,Chung-Wai Chow,
AMERICAN JOURNAL OF TRANSPLANTATIONno. 1 (2024): 89-103
Itthiphat Arunsurat,Nuttapol Rittayamai,Benjamas Chuaychoo, Suwat Tangchityongsiva,Simaporn Promsarn,Somruthai Yuenyong,Chung-Wai Chow,Laurent Brochard
Teresa To,Cornelia M. Borkhoff,Chung-Wai Chow,Theo J. Moraes,Robert Schwartz, Nick Vozoris, Avtar Lal, Wendy Yen, Kimball Zhang,Emilie Terebessy,Jingqin Zhu
European Journal of Pediatricspp.1-6, (2024)
Natalia Belousova,Ella Huszti,Qixuan Li,Anastasiia Vasileva,Rasheed Ghany, Ramy Gabarin, Moustapha El Sanharawi,Clement Picard,David Hwang,Liran Levy,Shaf Keshavjee,Chung-Wai Chow,
EUROPEAN RESPIRATORY JOURNAL (2023)
Annals of the American Thoracic Society (2023)
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EUROPEAN RESPIRATORY JOURNAL (2023)
The Journal of Heart and Lung Transplantationno. 4 (2023): S524-S524
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