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As head of the ancient biomolecules laboratories at the University of Manchester, my interests revolve around the use of ancient proteins and DNA for the study of human history, particularly in their application to human impacts on biodiversity in the past through to the present. I am also currently a Royal Society University Senior Research Fellow which allows me to dedicate time to investigating the information content of the bone proteome, with a particular interest in protein decay in the extracellular matrix that spans forensic, archaeological and palaeontological applications through to better understanding modern repair mechanisms.
In 2008 I completed my NERC-funded PhD entitled ‘Species identification in ancient and degraded bone fragments using protein mass spectrometry’ in the Department of Biology, University of York which initially focussed on sequencing the small non-collagenous bone protein osteocalcin by LC-ESI-qTOF-MS and LC-MALDI-TOF-TOF-MS. I then re-directed this research to the study of bone collagen (I), because of its greater persistence in fossilised remains, and developed ZooMS (‘Zooarchaeology by Mass Spectrometry’), in which collagen peptides are fractionated by SPE and fingerprinted using MALDI-TOF-MS. Typical archaeological applications are to distinguish between morphologically-similar taxa such as the caprine species, sheep and goats, or the identification of taxa in limited but highly assemblages spanning much of the Pleistocene. During my postdoctoral research I refined this methodology to work on other collagen-based samples, ranging from mummified skin and leathers, meat and bone meal and gelatine-containing food products, as well as other mineralised tissues such as ostrich eggshell.
In 2010 I moved to the Faculty of Life Sciences here at the University of Manchester to take up a NERC-funded postdoctoral research fellowship on the assessment of biodiversity in Pleistocene Britain through comprehensive small-scale microsampling of vertebrate fossil remains. In 2013 I was awarded my Royal Society University Research Fellowship (until 2018) on 'Molecular Timers'.
In 2008 I completed my NERC-funded PhD entitled ‘Species identification in ancient and degraded bone fragments using protein mass spectrometry’ in the Department of Biology, University of York which initially focussed on sequencing the small non-collagenous bone protein osteocalcin by LC-ESI-qTOF-MS and LC-MALDI-TOF-TOF-MS. I then re-directed this research to the study of bone collagen (I), because of its greater persistence in fossilised remains, and developed ZooMS (‘Zooarchaeology by Mass Spectrometry’), in which collagen peptides are fractionated by SPE and fingerprinted using MALDI-TOF-MS. Typical archaeological applications are to distinguish between morphologically-similar taxa such as the caprine species, sheep and goats, or the identification of taxa in limited but highly assemblages spanning much of the Pleistocene. During my postdoctoral research I refined this methodology to work on other collagen-based samples, ranging from mummified skin and leathers, meat and bone meal and gelatine-containing food products, as well as other mineralised tissues such as ostrich eggshell.
In 2010 I moved to the Faculty of Life Sciences here at the University of Manchester to take up a NERC-funded postdoctoral research fellowship on the assessment of biodiversity in Pleistocene Britain through comprehensive small-scale microsampling of vertebrate fossil remains. In 2013 I was awarded my Royal Society University Research Fellowship (until 2018) on 'Molecular Timers'.
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Eric Guiry, Ryan Kennedy,David Orton, Philip Armitage, John Bratten, Charles Dagneau, Shannon Dawdy,Susan deFrance, Barry Gaulton, David Givens, Olivia Hall, Anne Laberge,
Science advancesno. 14 (2024): eadm6755-eadm6755
Eric Guiry, Ryan Kennedy,David Orton, Philip Armitage, John Bratten, Charles Dagneau, Shannon Dawdy,Susan deFrance, Barry Gaulton, David Givens, Olivia Hall, Anne Laberge,
Science Advancesno. 14 (2024)
Journal of Archaeological Science: Reports (2023): 103943-103943
Elizabeth Johnston,Michael Buckley
Molecules (Basel, Switzerland)no. 13 (2023): 4899-4899
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