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个人简介
We are interested in understanding the biochemistry, physiology, and molecular biology of nuclear hormone (estrogen, progesterone) receptors, intracellular proteins that mediate the biological actions of these hormones in target cells, and the mechanisms by which these proteins regulate gene expression and the growth and functioning of target cells, especially cells of the reproductive system and mammary gland, and of tumors that develop in these tissues. Our studies focus on the characterization of these receptors and their coregulator protein partners; the interaction of receptor agonist versus antagonist ligand complexes with hormone-regulated genes; the interrelationships among hormones, growth factors, and various signal transduction pathways in the regulation of proliferation and phenotypic properties of breast cancer cells and tumors; and the mechanisms by which antihormones (antiestrogens and antiprogestins) antagonize hormone-dependent gene transcription and cell growth. We are doing genome-wide analyses of receptor and other transcription factor cistromes (chromatin binding sites by ChIP-Seq) and transcriptomes (gene expression, miRNAs, other RNAs by RNA-Seq) and are examining the bidirectional cross-talk between nuclear hormone receptors and cell signaling pathways. Our studies involve detailed biochemical and structure-function analyses of the receptors (and of mutant receptor forms) and coregulators and their gene interactions, and examination of their biological activities in normal and cancer, in particular breast cancer, cells and tumors. We have a major interest in hormones and breast cancer and in mechanisms of endocrine sensitivity and resistance to cancer therapies; biomarker discovery and improving cancer treatment effectiveness; and also a strong focus on reproductive biology and the improvement of fertility.
研究兴趣
论文共 478 篇作者统计合作学者相似作者
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Adam R. Karpf, Makenzie Vorderbruggen, Pedram Rikhtechi, Catalina Munoz-Trujillo,Cassie Liu,Larry H. Matherly,Sung Hoon Kim,Benita S. Katzenellenbogen,John A. Katzenellenbogen, Jered C. Garrison
CANCER RESEARCHno. 5 (2024)
Chanaelle Febrissy,Marine Adlanmerini,Christel Pequeux,Frederic Boudou,Melissa Buscato,Adrien Gargaros,Silveric Gilardi-Bresson, Khrystyna Boriak,Henrik Laurell,Coralie Fontaine,Benita S. Katzenellenbogen,John A. Katzenellenbogen,
THERANOSTICSno. 1 (2024): 249-264
Theranosticsno. 1 (2024): 249-264
Seema Irani,Wuwei Tan,Qing Li,Weiyi Toy, Catherine Jones,Mayur Gadiya,Antonio Marra,John A. Katzenellenbogen,Kathryn E. Carlson,Benita S. Katzenellenbogen,Mostafa Karimi,Ramya Segu Rajappachetty,
JOURNAL OF CLINICAL INVESTIGATIONno. 1 (2024)
Cancer Researchno. 7_Supplement (2023): 1476-1476
Makenzie Vorderbruggen, Cassie Liu, Catalina Muñoz Trujillo,Sung Hoon Kim,John A. Katzenellenbogen,Benita S. Katzenellenbogen,Adam R. Karpf
Cancer Researchno. 7_Supplement (2023): 3984-3984
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CANCER RESEARCHno. 7 (2023)
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J.C. Nwachukwu, Jacqline W Njeri, Thomas Venables, Ciaran P. Seath,Matthew E. Pipkin,Yingwei Hou,Benita S. Katzenellenbogen,John A. Katzenellenbogen, K.W. Nettles
Journal of the Endocrine Societyno. Supplement_1 (2023)
Breast cancer research and treatmentno. 3 (2023): 607-621
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