基本信息
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职业迁徙
个人简介
Research Areas: Calcium, Calcium channels, Calcium Signaling, Signal transduction
Research Interests
Signal transduction mechanisms in immune cells
Research Summary
The general focus of the laboratory is physiological processes that regulate lymphocyte and macrophage development and function. We are specifically interested in pathways that regulate calcium signaling in T and B cells and the mechanisms by which diverse and complex inputs (antigen and coactivating and inhibitory stimuli) are encoded as functionally specific Ca2+ signals and translated into appropriate biological responses that regulate lymphocyte development and differentiation. We are also interested in the viral and cellular determinants of viral tropism and pathogenesis. We have focused on the signal transduction pathways activated in human macrophages and T cells by HIV-1 envelope protein (gp120) upon interaction with CD4 and chemokine receptors. Our goal is to understand the functional consequences of signaling on virus entry, post-entry steps of viral replication, and the consequences on target cell functions apart from infection.
Research Interests
Signal transduction mechanisms in immune cells
Research Summary
The general focus of the laboratory is physiological processes that regulate lymphocyte and macrophage development and function. We are specifically interested in pathways that regulate calcium signaling in T and B cells and the mechanisms by which diverse and complex inputs (antigen and coactivating and inhibitory stimuli) are encoded as functionally specific Ca2+ signals and translated into appropriate biological responses that regulate lymphocyte development and differentiation. We are also interested in the viral and cellular determinants of viral tropism and pathogenesis. We have focused on the signal transduction pathways activated in human macrophages and T cells by HIV-1 envelope protein (gp120) upon interaction with CD4 and chemokine receptors. Our goal is to understand the functional consequences of signaling on virus entry, post-entry steps of viral replication, and the consequences on target cell functions apart from infection.
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论文共 87 篇作者统计合作学者相似作者
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Bryson W. Katona,Rebecca A. Glynn, Kayla E. Paulosky,Zijie Feng, Caroline I. Davis,Jian Ma,Corbett T. Berry,Katherine M. Szigety,Smita Matkar, Yuanyuan Liu,Haoren Wang,Yuan Wu,
crossref(2023)
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