Bruce Blumberg
教授
Developmental Biology Center
University of California, Irvine;Department of Developmental and Cell Biology, School of Biological Sciences, University of California, Irvine;Department of Biomedical Engineering, School of Biological Sciences, University of California, Irvine;Department of Pharmaceutical Sciences, School of Biological Sciences, University of California, Irvine;Institute for Genomics and Bioinformatics, University of California, Irvine
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One major research interest in the Blumberg laboratory concerns gene-environment interactions and the developmental basis of health and disease. Obesity and obesity-related disorders such as type 2 diabetes and coronary artery disease have become an epidemic of global proportions. Excessive consumption of calorie-dense food and diminished physical activity (the “Couch Potato model”) are the generally accepted causal factors for obesity. But can environmental factors play a role in exposing preexisting genetic differences or amplifying the effects of diet and excerise? Our “obesogen hypothesis” proposes the existence of environmental chemicals that can perturb lipid homeostasis, adipocyte development and adipose tissue function. We identified organotins as bona fide obesogens that cause adipocyte differentiation in vitro and fat accumulation in vivo. Moreover, prenatal exposure to organotins reprograms metabolism such that affected animals are predisposed to weight gain later in life, despite a normal diet. Effects of prenatal obesogen exposure can be transmitted transgenerationally through at least 4 subsequent generations by altering large scale chromatin structure to promote a “thrifty phenotype”. Understanding the role of these environmental obesogens in regulating fat cell development will provide important insights into a novel contributing factor for obesity.
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论文共 219 篇作者统计合作学者相似作者
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Bruce Blumberg,Richard Cheng-An Chang,Riann Egusquiza, Angélica Amato,Zhuorui Li,Erika Joloya, Hailey Wheeler, Angela Nguyen,Keiko Shioda,Junko Odajima, Michael Lawrence,Toshi Shioda
biorxiv(2023)
Frontiers in endocrinology (2023): 1184546-1184546
Handbook of Obesitypp.441-448, (2023)
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