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Our goal is to define structural determinants and functional consequences of lipid binding (covalent and non-covalent) to proteins. We are using multidisciplinary approach using chemical biology, biochemistry, cell biology and mass spectrometry to unequivocally identify lipids bound to motif-containing protein candidates and to understand functions of such protein-lipid interactions. Candidate proteins under investigation are cell surface receptors such as proteins of the family of metabotropic glutamate receptors. A potential function of non-annular lipids as cofactors for receptor activity, e.g. by facilitating dimerisation/assembly of (e.g. signalling-) active complexes makes these protein-lipid interactions a novel target for the development of small molecule-based drugs with a future perspective for translational medicine approaches.
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论文共 159 篇作者统计合作学者相似作者
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Dönem Avci, Ronny Heidasch, Martina Costa, Christian Lüchtenborg,Dipali Kale,Britta Brügger,Marius K. Lemberg
The Journal of biological chemistryno. 2 (2024): 105644-105644
Zina M. Uckeley,Maëva Duboeuf, Yu Gu, Alexandra Erny,Magalie Mazelier, Christian Lüchtenborg,Sophie L. Winter,Paulina Schad,Cyrille Mathieu,Jana Koch,Steeve Boulant,Petr Chlanda,
Thomas Kupke, Rabea M. Götz, Florian M. Richter,Rainer Beck,Fabio Lolicato,Walter Nickel,Carsten Hopf,Britta Brügger
Arpita Chowdhury, Angela Boshnakovska,Abhishek Aich, Aditi Methi, Ana Maria Vergel Leon,Ivan Silbern,Christian Lüchtenborg,Lukas Cyganek,Jan Prochazka,Radislav Sedlacek,Jiri Lindovsky, Dominic Wachs,
EMBO molecular medicineno. 9 (2023)
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ACCOUNTS OF CHEMICAL RESEARCHno. 9 (2023): 983-983
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Nastassja Himmelreich, Frauke Kikul,Lucie Zdrazilova,Tomáš Honzik, Andreas Hecker,Gernot Poschet,Christian Lüchtenborg,Britta Brügger,Sabine Strahl, Friederike Bürger,Jürgen G. Okun,Hana Hansikova,
Molecular Genetics and Metabolismno. 3 (2023): 107610-107610
Journal of cell scienceno. 10 (2023)
Steffen Klein,Gonen Golani,Fabio Lolicato,Carmen Lahr,Daniel Beyer, Alexia Herrmann,Moritz Wachsmuth-Melm,Nina Reddmann,Romy Brecht, Mehdi Hosseinzadeh,Androniki Kolovou,Jana Makroczyova,
Cell host & microbeno. 4 (2023): 616-633.e20
Sarah Goellner,Giray Enkavi,Vibhu Prasad,Solène Denolly, Sungmin Eu, Giulia Mizzon, Leander Witte,Waldemar Kulig,Zina M. Uckeley,Teresa M. Lavacca,Uta Haselmann,Pierre-Yves Lozach,
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