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Each human nucleus contains two meters of DNA that, amazingly, is packaged into an organelle a mere ~10 μm diameter. Yet, despite this dramatic difference in scale, the three-dimensional organization of the genome is non-random and plays a critical functional role in both health and disease. However, as much of our current view of nuclear organization is derived from ensemble techniques requiring populations of millions or more cells, much less is known about the organization of chromosomes in individual cells and many open questions remain about the mechanisms that shape and structure the genome. Our laboratory uses a combination of computational, molecular, and optical approaches to investigate the causes and consequences of 3D genome organization in single cells.
Each human nucleus contains two meters of DNA that, amazingly, is packaged into an organelle a mere ~10 μm diameter. Yet, despite this dramatic difference in scale, the three-dimensional organization of the genome is non-random and plays a critical functional role in both health and disease. However, as much of our current view of nuclear organization is derived from ensemble techniques requiring populations of millions or more cells, much less is known about the organization of chromosomes in individual cells and many open questions remain about the mechanisms that shape and structure the genome. Our laboratory uses a combination of computational, molecular, and optical approaches to investigate the causes and consequences of 3D genome organization in single cells.
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论文共 55 篇作者统计合作学者相似作者
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Methods in molecular biology (Clifton, N.J.) (2024): 177-189
Serena F. Generoso,Maria Victoria Neguembor,Elliot A. Hershberg,Ruslan I. Sadreyev,Kazuki Kurimoto,Yukihiro Yabuta, Raffaele Ricci, Pauline Audergon,Moritz Bauer,Mitinori Saitou,Konrad Hochedlinger,Brian J. Beliveau,
Journal of Biological Chemistryno. 3 (2023): 104248-S678
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Molecular cellno. 15 (2023): 2624-2640
biorxiv(2023)
biorxiv(2023)
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