Dr. Callaghan’s research is focused on the metabolic factors that are associated with neuropathy. He has completed four observational studies that have demonstrated that hyperglycemia, obesity, and the number of metabolic syndrome components (increased blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol levels), but not hypertension or dyslipidemia, are associated with neuropathy. This has led to a proposed interventional study of surgical weight loss and/or high-intensity interval training to determine if either intervention can prevent nerve injury. If successful, either intervention would be the first disease-modifying therapy for neuropathy.