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Tuberculosis remains a threat to global health, killing ~2 million people every year. The causative agent of tuberculosis, Mycobacterium tuberculosis, is thought to infect one-third of the world's population, sickening ~10 million people a year. Despite efforts to simplify treatment strategies, tuberculosis still requires months of multi-drug therapy to cure. Our research focuses on designing optimized therapies for TB using cell biology and engineering approaches. Our lab is a multidisciplinary research team, integrating quantitative measurement with computational modeling and analysis to create intuitive descriptions of complex cell biology. We focus our studies on (1) characterizing single-cell determinants of mycobacterial drug tolerance, (2) understanding how growth heterogeneity is controlled, and (3) engineering combination therapy.
Tuberculosis remains a threat to global health, killing ~2 million people every year. The causative agent of tuberculosis, Mycobacterium tuberculosis, is thought to infect one-third of the world's population, sickening ~10 million people a year. Despite efforts to simplify treatment strategies, tuberculosis still requires months of multi-drug therapy to cure. Our research focuses on designing optimized therapies for TB using cell biology and engineering approaches. Our lab is a multidisciplinary research team, integrating quantitative measurement with computational modeling and analysis to create intuitive descriptions of complex cell biology. We focus our studies on (1) characterizing single-cell determinants of mycobacterial drug tolerance, (2) understanding how growth heterogeneity is controlled, and (3) engineering combination therapy.
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论文共 65 篇作者统计合作学者相似作者
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Kathleen P. Davis, Yoelkys Morales, Rachel J. Ende, Ryan Peters,Anne L. Mccabe,Joan Mecsas,Bree B. Aldridge
MBIOno. 3 (2024): e0015924-e0015924
Megan W Tse,Meilin Zhu, Benjamin Peters,Efrat Hamami, Julie Chen, Kathleen P Davis, Samuel Nitz,Juliane Weller,Thulasi Warrier, Diana K Hunt, Yoelkys Morales, Tomohiko Kawate,
bioRxiv : the preprint server for biology (2024)
Soorya Janakiraman,Sophie Engels,Pariksheet Nanda,Maral Budak,Talia Greenstein, Mariana Pereira Moraes,Bree B Aldridge,Denise E Kirschner
STAR protocolsno. 3 (2023): 102442-102442
bioRxiv : the preprint server for biology (2023)
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
BMC microbiologyno. 1 (2022): 140-140
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