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个人简介
Our lab research has focused on innate immune responses to infection and injury. Over the past several years, we have extended our interest in innate responses to the cancer microenvironment with the overall goals of understanding mechanisms that drive tumor progression and developing novel prognostic biomarkers and therapeutic approaches. We find that the immune pathways that mediate antimicrobial host defense can also promote metastasis and impair anti-tumor immunity. Our most recent work points to neutrophils acquiring a suppressor function within the tumor microenvironment that results in suppression of T cell proliferation and activation required for anti-tumor immunity. We identified mechanisms driving this neutrophil suppressor phenotype, including complement signaling, that are potential targets for therapeutic modulation to enhance anti-tumor immunotherapy.
研究兴趣
论文共 256 篇作者统计合作学者相似作者
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G. Aaron Holling,Colin A. Chavel, Anand P. Sharda, Mackenzie M. Lieberman, Caitlin M. James, Shivana M. Lightman, Jason H. Tong,Guanxi Qiao,Tiffany R. Emmons,Thejaswini Giridharan,Shengqi Hou,Andrew M. Intlekofer,
Cellular & Molecular Immunologyno. 3 (2024): 260-274
Sarah Werner,Nicole Gaulin, Jessie Chiello, Theja Giridharan,Anm Nazmul Khan,Sora Suzuki, Suzanne Hess, Sol Langermann,Emese Zsiros,Brahm H. Segal,A. J. Robert McGray
CANCER RESEARCHno. 5 (2024)
GYNECOLOGIC ONCOLOGY (2023): 92-99
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Albina N. Minlikeeva,Jo L. Freudenheim,Kevin H. Eng,Rikki A. Cannioto, Grace Friel,J. Brian Szender,Brahm Segal,Kunle Odunsi,Paul Mayor,Brenda Diergaarde,Emese Zsiros,Linda E. Kelemen,
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Cancer Research Communicationsno. 3 (2023): 510-520
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