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Bernstein’s research focuses on epigenetics — changes in gene activity governed by influences outside the genes themselves — and specifically how modifications to the protein scaffold called chromatin contribute to mammalian development and human cancer. Bernstein’s laboratory is characterizing epigenetic mechanisms that underlie stem cells’ ability to give rise to almost any kind of cell, and exploring how epigenetic mechanisms contribute to malignant transformation and tumor progression. His work is notable for the discovery of bivalent domains that poise developmental genes for alternate fates in stem cells, for the systematic identification of enhancer “switches” in the human genome that control cell type-specific gene activity, and for the characterization of epigenetic aberrations that lead to cancer.
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论文共 289 篇作者统计合作学者相似作者
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JOURNAL OF BONE AND MINERAL RESEARCHno. 1 (2024): 1-13
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crossref(2023)
CELL GENOMICSno. 7 (2023): 100321-100321
biorxiv(2023)
crossref(2023)
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Nature Immunologyno. 8 (2023): 1-9
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Neuro-oncologyno. Supplement_5 (2023): v85-v86
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