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个人简介
Our lab works on gene regulation in the hematopoietic system. We study how transcription factors and chromatin components drive differential gene expression during blood cell development, both in a normal, but also in a disease setting. We are particularly interested into studying at the genome-wide level, how mutant transcription factors that cause acute myeloid leukaemia reprogram the chromatin landscape and gene expression of normal cells and maintain aberrant malignant phenotypes. To answer these questions, we use a number of different techniques, from classical molecular biology, to sophisticated cell culture such as embryonic stem cell differentiation to working with primary cells from leukaemia patients.
研究兴趣
论文共 237 篇作者统计合作学者相似作者
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Nicholas Davies, Tegan Francis,Ceri Oldreive, Maria Azam, Jordan Wilson,Philip J Byrd,Megan Burley,Archana Sharma-Oates,Peter Keane, Sael Alatawi,Martin R Higgs,Zbigniew Rudzki,
Haematologica (2024)
LEUKEMIAno. 2 (2024): 403-407
Daniel J.L. Coleman,Peter Keane,Paulynn S. Chin,Luke Ames,Sophie Kellaway,Helen Blair,Naeem Khan,James Griffin, Elizabeth Holmes, Alexander Maytum,Sandeep Potluri, Lara Strate,
iScienceno. 4 (2024): 109576-109576
Leukemiano. 2 (2024): 403-407
HEMATOLOGIEno. 1 (2023): 26-26
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Nature communicationsno. 1 (2023): 6947-18
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