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Here he witnessed the first establishment of the Lgr5+ cell-derived intestinal organoid culture system pioneered by Dr. Toshiro Sato and Prof. Hans Clevers. In the following years Dr. Koo has utilised this novel culture system to perform sophisticated gene correction studies, to unravel the molecular regulation of adult stem cells and to proof the stem cell properties of a Troy+, quiescent reserve stem cell population in the stomach. Together with his group at the University of Cambridge he is now developing novel genetic tools to further investigate how proliferating and quiescent adult epithelial stem cell populations are regulated both in homeostasis and during injury mediated repair.
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论文共 136 篇作者统计合作学者相似作者
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Mathilde Meyenberg, Anna Hakobyan,Nikolina Papac-Milicevic,Laura Göderle, Franziska L Langner, Mateo Markovic,Ji-Hyun Lee,Bon-Kyoung Koo,Georg A Busslinger,Israel Tojal da Silva,Christoph J Binder,Jörg Menche,
Scientific reportsno. 1 (2023): 13964-13964
Isaree Teriyapirom,Jihoon Kim,Heetak Lee,Sebastian R. Merker,Amanda Andersson-Rolf, Stephan R. Jahn,Anne-Marlen Ada, Sang-Min Kim,Joo Yeon Lim, Tim Schmaeche, Nancy Wetterling, Saskia Stegert,
biorxiv(2023)
DEVELOPMENTno. 22 (2023)
Szu-Hsien Sam Wu,Somi Kim,Heetak Lee,Ji-Hyun Lee,Gabriele Colozza,So-Yeon Park,Réka Bakonyi,Isaree Teriyapirom, Natalia Hallay, Sandra Pilat-Carrota, Hans-Christian Theussl,Jihoon Kim,
crossref(2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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biorxiv(2023)
SCIENCE ADVANCESno. 47 (2023): eadi8454-eadi8454
Wanyoung Lim,Inwoo Hwang,Jiande Zhang,Zhenzhong Chen, Jeonghun Jeonghun,Bon-Kyoung Koo, Sangmin Kim,Jeong Eon Lee,Kenneth j. Pienta,Sarah R Amend,Robert H. Austin,Jee-Yin Ahn,
biorxiv(2022)
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