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I am currently an Assistant Professor in the Department of Biochemistry at Emory University School of Medicine. I am also the Co-Scientific Adviser of the Robert P. Apkarian Integrated Electron Microscopy Core (IEMC) at Emory University. I am broadly interested in the structural basis and physiological function of biologically important complexes in space and time. My research interests focus on integrated approaches of cryo-electron microscopy (cryo-EM), x-ray crystallography and fluorescence light microscopy to uncover the molecular mechanisms of human disease associated macromolecular machineries. I am also interested in sampling and deciphering the structural and dynamic aspects of molecules that are critical for their biological function in real time at single molecule level. I have the motivation, expertise, leadership, and training essential to successfully lead the research programs in the Liang laboratory at Emory.
I have a successful track record of interdisciplinary research and creativity throughout my scientific career. Prior to joining Emory, I was a postdoctoral fellow at Harvard Medical School. I received rigorous trainings under the supervision of Professors Stephen Harrison and Sean Whelan, where I mainly focused on the structural and functional analysis of a multifunction viral RNA polymerase, the L protein of vesicular stomatitis virus (VSV), using single particle cryo-EM. Two significant contributions resulted from this work: 1) the determination of the first near-atomic cryo-EM structure of an asymmetric protein with less than 250 kDa, which represents a landmark in the evolution of cryo-EM; 2) the first atomic view of the RNA synthesis machinery of non-segmented negative-sense (NNS) RNA viruses. Prior to my postdoctoral training, I obtained my Ph.D. degree in Molecular Biophysics in the Institute of Molecular Biophysics at Florida State University. As a graduate student and two-time American Heart Association predoctoral fellow with Professor Hong Li, I received outstanding training in x-ray crystallography where I focused on box H/ACA ribonucleoproteins (RNPs) that are essential for ribosome and spliceosome maturation. My primary contribution was the determination of a set of crystal structures which represent key stages of the box H/ACA RNP assembly and function. Before that, I earned dual bachelor’s degrees in Biology and Computer Science at University of Science and Technology of China, where intensive multidisciplinary trainings provided me with a solid background in biology and life sciences, and critical skills in computer scripting and coding.
I am also a team player and service provider. I have successfully collaborated with many researchers and produced several peer-reviewed publications from each project. I have published high-impact articles in top journals such as Cell, Nature Structural and Molecular Biology, Molecular Cell, PNAS and so on. I have routinely attended national and international conferences and meetings. I serve as a reviewer for many national and international scientific peer-reviewed journals, and an editorial board member of the Journal of Molecular Cell Biology. Throughout my career, I have participated in multiple important services aside my scientific research. For example, I served as the president of a student organization during graduate school, a trainee committee member of Biological Chemistry and Molecular Pharmacology (BCMP) at Harvard Medical School and the chair of the Harvard Medical Postdoctoral Association.
I have a successful track record of interdisciplinary research and creativity throughout my scientific career. Prior to joining Emory, I was a postdoctoral fellow at Harvard Medical School. I received rigorous trainings under the supervision of Professors Stephen Harrison and Sean Whelan, where I mainly focused on the structural and functional analysis of a multifunction viral RNA polymerase, the L protein of vesicular stomatitis virus (VSV), using single particle cryo-EM. Two significant contributions resulted from this work: 1) the determination of the first near-atomic cryo-EM structure of an asymmetric protein with less than 250 kDa, which represents a landmark in the evolution of cryo-EM; 2) the first atomic view of the RNA synthesis machinery of non-segmented negative-sense (NNS) RNA viruses. Prior to my postdoctoral training, I obtained my Ph.D. degree in Molecular Biophysics in the Institute of Molecular Biophysics at Florida State University. As a graduate student and two-time American Heart Association predoctoral fellow with Professor Hong Li, I received outstanding training in x-ray crystallography where I focused on box H/ACA ribonucleoproteins (RNPs) that are essential for ribosome and spliceosome maturation. My primary contribution was the determination of a set of crystal structures which represent key stages of the box H/ACA RNP assembly and function. Before that, I earned dual bachelor’s degrees in Biology and Computer Science at University of Science and Technology of China, where intensive multidisciplinary trainings provided me with a solid background in biology and life sciences, and critical skills in computer scripting and coding.
I am also a team player and service provider. I have successfully collaborated with many researchers and produced several peer-reviewed publications from each project. I have published high-impact articles in top journals such as Cell, Nature Structural and Molecular Biology, Molecular Cell, PNAS and so on. I have routinely attended national and international conferences and meetings. I serve as a reviewer for many national and international scientific peer-reviewed journals, and an editorial board member of the Journal of Molecular Cell Biology. Throughout my career, I have participated in multiple important services aside my scientific research. For example, I served as the president of a student organization during graduate school, a trainee committee member of Biological Chemistry and Molecular Pharmacology (BCMP) at Harvard Medical School and the chair of the Harvard Medical Postdoctoral Association.
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