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Siesjö's research focus was on cerebral metabolism in the normal and injured brain, and an early important topic of his interest was the regulation of pH in the extra- and intracellular fluids in the brain. He published a textbook on the brain's energy metabolism and authored or co-authored more than 500 publications listed on PubMed. In 1970s his research focused on the ischemic metabolic cascade, the mechanisms of ischemic cell death, and the energy reserves in the brain, work that bore rich fruit. Two classic papers from this period stand out for their influence on the field, ie, his 1981 paper with Astrup and Symon on the concept of the ischemic penumbra,1 and his synthesis paper on the mechanisms of ischemic cell death.2 In his later years of research he also investigated the pathophysiology of chronic brain diseases, such as dementia of the Alzheimer's type. In his research carrier, Siesjö became one of the most highly cited scientists in his field.
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M Fujioka,Kazuhide Hayakawa,Kazuo Mishima, A Kunizawa,Carl Muroi,Keiichi Irie, Shin Higuchi,Takafumi Nakano,Fumiaki Banno,Koichi Kokame, Toshiko Miyata,Yasuhiro Yonekawa,
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A Kunizawa, Sachiko Suzuki, Akio Asai,Keiji Kawamoto, Yusuke Kitazawa, G W Ickenstein,Bo K Siesjo, M Fujioka
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MATURATION PHENOMENON IN CEREBRAL ISCHEMIA IV: APOPTOSIS AND/OR NECROSIS, NEURONAL RECOVERY VS. DEATH, AND PROTECTION AGAINST INFARCTIONpp.229-240, (2001)
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