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个人简介
Honors & Awards
Research Fellow, The Alfred P. Sloan Foundation (2002)
Young Investigator Award, The Arnold and mabel Beckman Foundation (2002)
Speaker's Fund for Biomedical Research Award, New York Academy of Sciences (2002)
Career Scientist Award, Monique Weill-Caulier Trust (2002)
McKnight Scholar Award, The McKnight Endowment Fund for Neurosciences (2002)
Brain Disorders Award, The McKnight Endowment Fund for Neurosciences (2008)
Our laboratory is interested in understanding how the diverse neuronal cell types are generated and maintained in the nervous system. We are taking a combined molecular, cellular, genetic, and genomic approach in the model organisms Drosophila and mouse. To study how neuronal diversity is generated, we focus on investigating the mechanisms of asymmetric division of neural stem cell that balances the self-renewal and differentiation potentials of neural stem cells. Of particular interest to us is the mechanism by which aberrant regulation of neural stem cell asymmetric division leads to brain tumor-like phenotypes. To study how neurons are properly maintained after they are integrated into neural networks, we are creating neurodegenerative phenotypes in Drosophila similar to that observed in Alzheimers and Parkinsons diseases in humans. We are employing the power of fly genetics to identify genetic modifiers that can suppress or enhance these disease phenotypes. Given the unanticipated high level conservation of signaling pathways, regulatory mechanisms, and physiological processes between flies and mammals, our research promises to provide insights into fundamental mechanisms that control the generation and maintenance of neuronal diversity in humans.
Research Fellow, The Alfred P. Sloan Foundation (2002)
Young Investigator Award, The Arnold and mabel Beckman Foundation (2002)
Speaker's Fund for Biomedical Research Award, New York Academy of Sciences (2002)
Career Scientist Award, Monique Weill-Caulier Trust (2002)
McKnight Scholar Award, The McKnight Endowment Fund for Neurosciences (2002)
Brain Disorders Award, The McKnight Endowment Fund for Neurosciences (2008)
Our laboratory is interested in understanding how the diverse neuronal cell types are generated and maintained in the nervous system. We are taking a combined molecular, cellular, genetic, and genomic approach in the model organisms Drosophila and mouse. To study how neuronal diversity is generated, we focus on investigating the mechanisms of asymmetric division of neural stem cell that balances the self-renewal and differentiation potentials of neural stem cells. Of particular interest to us is the mechanism by which aberrant regulation of neural stem cell asymmetric division leads to brain tumor-like phenotypes. To study how neurons are properly maintained after they are integrated into neural networks, we are creating neurodegenerative phenotypes in Drosophila similar to that observed in Alzheimers and Parkinsons diseases in humans. We are employing the power of fly genetics to identify genetic modifiers that can suppress or enhance these disease phenotypes. Given the unanticipated high level conservation of signaling pathways, regulatory mechanisms, and physiological processes between flies and mammals, our research promises to provide insights into fundamental mechanisms that control the generation and maintenance of neuronal diversity in humans.
研究兴趣
论文共 122 篇作者统计合作学者相似作者
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Suman Rimal,Wen Li, Tejender Pal Khaket,Yu Li,Ishaq Tantray, Yanping Li,Sunil Bhurtel,Lea T Grinberg,Salvatore Spina,Maria Inmaculada Cobos Sillero,William W Seeley,Su Guo,
Ageing and Neurodegenerative Diseasesno. 1 (2024)
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The Journal of biological chemistryno. 3 (2024): 105719-105719
Nature Communicationsno. 1 (2024): 1-17
Yeongmi Cheon,Sunggyu Yoon, Jae-Hyuk Lee,Kiyoung Kim,Hyung-Jun Kim, Sung Wook Hong,Ye-Rang Yun,Jiwon Shim,Sung-Hak Kim,Bingwei Lu,Mihye Lee,Seongsoo Lee
eNeurono. 8 (2023)
The Journal of biological chemistryno. 3 (2023): 102995-10
Sofia Carolina Granados-Mendoza,William Florez-Perdomo,Vishal Chavda,Bingwei Lu,Tariq Janjua,Amit Agrawal,Luís Rafael Moscote-Salazar
Journal of Neurointensive Care (Online)no. 1 (2023): 26-34
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