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职业迁徙
个人简介
Dr. Law obtained her Ph.D. Degree from The University of Hong Kong in 2009. She is now
working on novel drug discovery from Chinese medicinal herbs and autophagy signaling pathway.
With recent research focuses on the identification of novel autophagic enhancers from Chinese
medicinal herbs using bioactivity-guided purification, she has identified a novel autophagic
inducer, alisol B, from the rhizome of Alisma orientale as a potential antitumor agent, which can
induce Endoplasmic Reticulum stress (ER stress) and calcium mobilization from internal stores,
leading to autophagy through the CaMKK-AMPK-mammalian target of rapamycin (mTOR)
signaling pathway. Her study provides detailed insights into the cytotoxic mechanism of a novel
antitumor compound and was published in the Molecular Cancer Therapeutic 2010. Besides, she
is also interested in studying the therapeutic applications of the identified autophagic modulators
by using both in vitro and in vivo approaches. Her current research focus would be on identifying
novel autophagic enhancers to modulate neurodegenerative disorders through the removal of
mutant or misfolded protein by autophagy.
Research Interests
Cellular regulation and signaling of autophagy
Molecular mechanisms that underlie autophagy and neurodegenerative diseases
Novel drug discovery from Chinese medicinal herbs for neurological disorders
Research Fields:
Molecular Biology and Pharmacology
研究兴趣
论文共 119 篇作者统计合作学者相似作者
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Hui Miao Wang, Hong Juan Lai,An Guo Wu,Yong Tang,Lin Lin Song,Hang Hong Lo, Io Nam Wong,Vincent Kam Wai Wong,Betty Yuen Kwan Law
JOURNAL OF FUNCTIONAL FOODS (2024): 105962
Phytomedicine (2024): 155463-155463
Chunxia Jiang, Xiumei Ma, Jiao Chen, Yan Zeng, Man Guo, Xiaozhen Tan, Yuping Wang, Peng Wang, Pijun Yan, Yi Lei, Yang Long,Betty Yuen Kwan Law,
DIABETES METABOLIC SYNDROME AND OBESITY (2024): 1051-1068
Ruihong Chen,Hang Hong Lo, Chenxu Yang,Betty Yuen Kwan Law,Xi Chen, Calista Chi In Lam, Charles Ho, Hio Lam Cheong, Qianzi Li, Chenyu Zhong,Jerome Pak Lam Ng, Cheung Kam Fai Peter,
PHYTOMEDICINE (2024): 155310-155310
Neural regeneration researchno. 3 (2024): 501-502
Phytotherapy Researchno. 10 (2023): 4639-4654
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