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The Göttgens group uses a combination of experimental and computational approaches to study how transcription factor networks control the function of blood stem cells and how mutations that perturb such networks cause leukaemia. This integrated approach has resulted in the discovery of new combinatorial interactions between key blood stem cell regulators, as well as experimentally validated computational models for blood stem cells. Current research focuses on (i) single cell genomics of early blood development, (ii) modelling the transcriptional landscape of blood stem and progenitor cell differentiation, (iii) transcriptional consequences of leukaemogenic mutations in leukaemia stem/progenitor cells, and (iv) molecular characterisation of human blood stem/progenitor cell populations used in cell and gene therapy protocols.
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论文共 408 篇作者统计合作学者相似作者
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biorxiv(2024)
Iwo Kucinski,Joana Campos,Melania Barile, Francesco Severi, Natacha Bohin, Pedro N. Moreira,Lewis Allen,Hannah Lawson,Myriam L.R. Haltalli,Sarah J. Kinston,Dónal O'Carroll,Kamil R. Kranc,
Cell stem cellno. 2 (2024): 244-259.e10
bioRxiv : the preprint server for biology (2024)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Roshana Thambyrajah,Maria Maqueda,Wen Hao Neo, Kathleen J Imbach,Yolanda Guillen, Daniela Grases, Zaki Fadlullah,Stefano Gambera,Francesca Matteini,Xiaonan Wang,Fernando J Calero-Nieto,Manel Esteller,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Nature Cell Biologyno. 7 (2023): 1061-1072
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European journal of immunologyno. 1 (2023): e2350633-e2350633
CELL REPORTSno. 6 (2023)
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Luke Harland, Bart Theeuwes, Alexandra Bisia,Mai-Linh Ton,Ricard Argelaguet,Stephen Clark,Tim Lohoff,Nicola Wilson,Wolf Reik, Elizabeth Robertson,Bertie Gottgens
EXPERIMENTAL HEMATOLOGY (2023): S89-S89
EXPERIMENTAL HEMATOLOGY (2023): S88-S88
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