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In 1999 he moved to the Heinrich-Heine-University of Düsseldorf and started to work with human hematopoietic stem and progenitor cells. There, he also established his research group focusing on mechanisms controlling the decision of self-renewal versus differentiation of human somatic stem cells. In 2008 he moved with his group to the Institute of Transfusion Medicine at the University Hospital Essen. Here, he continues his studies on human somatic stem cells. Via the identification of two asymmetrically segregating proteins in dividing human hematopoietic stem and progenitor cells, the tetraspanins CD53 and CD63, he became interested in extracellular vesicles (EVs).
As a second topic, in 2009, his group started to work on purification and analysis methods for EVs, setting a focus on mesenchymal stem/stromal cell-derived EVs (MSC-EVs). Together with collaboration partners the group demonstrated the therapeutic potential of prepared MSC-EVs in a human GvHD-patient and in different animal models. Accordingly, Bernd Giebel has a strong track record in the purification, characterization and analysis of the therapeutic activity of EVs and has published several articles on this topic. Due to the overall increasing interest in EV biology, the group is involved in several projects on the campus and is actively cooperating with different German and international groups.
Dr. Giebel was a member of the ME-HAD COST Action and led the working group Diagnostic & Therapeutic Potential of Microvesicles and Exosomes (ME). Since 2012 he is an active member of the International Society of Extracellular vesicles (ISEV) and coordinated an ISEV position paper regarding the therapeutic application of EVs. Furthermore, he is the president of the German Society of Extracellular Vesicles (GSEV), which he founded together with other German EV experts on March 2nd 2017. According to his expertise, Dr. Giebel is part of the scientific advisory board of two SME companies being active in the EV field.
As a second topic, in 2009, his group started to work on purification and analysis methods for EVs, setting a focus on mesenchymal stem/stromal cell-derived EVs (MSC-EVs). Together with collaboration partners the group demonstrated the therapeutic potential of prepared MSC-EVs in a human GvHD-patient and in different animal models. Accordingly, Bernd Giebel has a strong track record in the purification, characterization and analysis of the therapeutic activity of EVs and has published several articles on this topic. Due to the overall increasing interest in EV biology, the group is involved in several projects on the campus and is actively cooperating with different German and international groups.
Dr. Giebel was a member of the ME-HAD COST Action and led the working group Diagnostic & Therapeutic Potential of Microvesicles and Exosomes (ME). Since 2012 he is an active member of the International Society of Extracellular vesicles (ISEV) and coordinated an ISEV position paper regarding the therapeutic application of EVs. Furthermore, he is the president of the German Society of Extracellular Vesicles (GSEV), which he founded together with other German EV experts on March 2nd 2017. According to his expertise, Dr. Giebel is part of the scientific advisory board of two SME companies being active in the EV field.
研究兴趣
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Jan Barekzai, Laura Refflinghaus, Maduwuike Okpara,Lars Tasto,Tobias Tertel,Bernd Giebel,Peter Czermak,Denise Salzig
Cytotherapy (2024)
BRAINno. 2 (2024): 372-389
Nina Hagemann,Yachao Qi,Ayan Mohamud Yusuf, AnRan Li,Anthony Squire,Tobias Tertel,Bernd Giebel,Peter Ludewig, Philippa Spangenberg,Jianxu Chen,Axel Mosig,Matthias Gunzer,
Arteriosclerosis, thrombosis, and vascular biologyno. 4 (2024): 915-929
Simon Heidegger,Florian Stritzke, Sarah Dahl,Juliane Daßler-Plenker, Laura Joachim,Dominik Buschmann, Kaiji Fan, Carolin M Sauer,Nils Ludwig,Christof Winter, Stefan Enssle, Suqi Li,
Cell reports. Medicineno. 9 (2023): 101171-101171
Cytotherapyno. 8 (2023): 810-814
Proceedings of the National Academy of Sciences of the United States of Americano. 40 (2023)
Cytotherapyno. 6 (2023): S121-S121
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Stem cells translational medicine (2023)
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