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The Kile lab's research has focused primarily on the molecular regulation of blood cell formation and function, at steady state, and in disease settings such as inflammation and leukemia. We have a deep interest in the role programmed cell death pathways play in these processes, and how the cell death machinery mediates the response to pathophysiological insults such as cancer chemotherapy. Our work has contributed to understanding the survival of platelets – the tiny cells that mediate blood clotting – and informed the clinical development of a new class of cancer drugs called the BH3 mimetics. We have identified critical roles for the cell death machinery in suppressing innate immune signalling, suggesting new therapeutic approaches to the treatment of viral infections and cancer.
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论文共 182 篇作者统计合作学者相似作者
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Communications Biologyno. 1 (2024): 1-13
Life science allianceno. 2 (2024): e202302411-e202302411
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Research Square (Research Square) (2023)
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Firas El-Mortada, Karima Landelouci, Samuel Bertrand-Perron, Félix-Antoine Aubé, Amélie Poirier, Amel Bidias,Georges Jourdi, Mélanie Welman,Michael P Gantier, Justin R Hamilton,Benjamin Kile, Marie Lordkipanidzé,
Life science allianceno. 2 (2023)
Tomalika R. Ullah,Matt D. Johansen,Katherine R. Balka,Rebecca L. Ambrose,Linden J. Gearing, James Roest,Julian P. Vivian, Sunil Sapkota,W. Samantha N. Jayasekara,Daniel S. Wenholz, Vina R. Aldilla,Jun Zeng,
Michael Gantier,Tomalika Ullah,Matt Johansen,Katherine Balka, Rebecca Ambrose,Linden Gearing, Daniel Wenholz, Jun Zeng, Stefan Miemczyk,Duc Nguyen, Rajan Venkatraman, Matthew Dennis,
Research Square (Research Square) (2022)
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