In the Hogan lab, researchers investigate the development of lymphatic vasculature and the blood brain barrier, which play important roles in the metastatic spread of cancer.
Specifically, we aim to:
Characterise signalling and transcriptional mechanisms that control lymphangiogenesis using studies in zebrafish and mice.
Discover new genes essential for development of the blood brain barrier using zebrafish genetics.
Develop imaging methods to visualise signalling in real time during tissue morphogenesis.
Model cellular pathologies of vasculature in cancer and vascular disease.