基本信息
浏览量:7
职业迁徙
个人简介
Regulation of the lifespan of proteins is key for most biological processes and when altered, can often associate with progression of diseases. When proteins reach the end of their lifetime, most of them get modified by the attachment of ubiquitin, a small protein of 76 amino acids. This modification has been implicated not just in the elimination of damaged proteins, but also in physiological proteolytic control of processes such as transcription, signal transduction, and cell cycle transitions. So far, analysis has principally focused on ubiquitin (ub) attachment, with several hundred ub conjugating enzymes characterized to date. Much less is known about enzymes that remove ub from substrate proteins, yet around a hundred genes have been identified, sharing consensus motifs for deubiquitylating enzymes (DUBs). Such diversity is inconsistent with a simple recycling function and strongly suggests a range of specific (but currently largely undiscovered) biological functions. Members of the DUB family are already known to contribute to neoplastic transformation and are implicated in neurodegenerative diseases, making them attractive targets for drug design.
研究兴趣
论文共 556 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Veronica Jové,Heather Wheeler, Chiachin Wilson Lee, David R. Healy,Kymberly Levine,Erik C. Ralph,Masaya Yamaguchi, Ziyue Karen Jiang, Edward Cabral, Yingrong Xu, Jeffrey Stock,Bing Yang,
iScienceno. Suppl 1 (2024): 109593-109593
Life Science Allianceno. 5 (2024)
Megat H B A Hamid,Pablo F Cespedes,Chen Jin,Ji-Li Chen,Uzi Gileadi,Elie Antoun,Zhu Liang, Fei Gao, Renuka Teague, Nikita Manoharan,David Maldonado-Perez, Nasullah Khalid-Alham,
Nature immunologypp.1-13, (2024)
Zhu Liang,Andreas Damianou,Iolanda Vendrell, Edward Jenkins,Frederik H. Lassen,Sam J. Washer, Athina Grigoriou,Guihai Liu, Gangshun Yi, Hantao Lou,Fangyuan Cao, Xiaonan Zheng,
Cell Reportsno. 5 (2024): 114152
Andreas Damianou,Zhu Liang,Frederik Lassen,Iolanda Vendrell, George Vere Svenja Hester,Philip Charles,Adan Pinto-Fernandez, Alberto Santos,Roman Fischer,Benedikt M. Kessler
crossref(2023)
Proceedings of the National Academy of Sciences of the United States of Americano. 50 (2023)
引用0浏览0WOS引用
0
0
Nature communicationsno. 1 (2023): 7710-7710
crossref(2023)
crossref(2023)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn