基本信息
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职业迁徙
个人简介
I prepared my PhD in the laboratory of Structure and Expression of Bacterial Genome directed by Dr. Françoise Le Hégarat at the University Paris XI where I studied histone-like proteins of the Gram positive bacteria Bacillus subtilis. I obtained my PhD in 1998. The same year I joined the laboratory of Prof. Charles J. Dorman in Trinity College Dublin as a European Post-doctoral fellow. During these three years my research has been focused on the regulation of virulence gene expression in the pathogenic bacteria Shigella flexneri. In 2001, I came back to France on a postdoctoral proposition in the 5 years group recently created by Dr. Jean-Marc Ghigo. I participated to the implementation of the G5 Genetics of Biofilms Laboratory. In 2003, I was recruited at the Institut Pasteur as Assistant Professor (Chargé de Recherche) and have been promoted Associate Professor in 2014. In the Ghigo’s laboratory, my work focuses on two biofilm-specific phenomena: initial adhesion to surfaces or between bacteria, which is a key step of any colonization process, and biofilms recalcitrance towards antibiotic , a major biofilm behavior responsible for chronic and recurrent infections in clinic. Beyond the importance of a better fundamental understanding of the molecular mechanisms controlling these two biofilm-properties , these studies have also been motivated by my desire to translate, when possible, some aspects of my work into clinically relevant situations involving biofilms. Since 2011 I’m strongly involved in teaching at the Institut Pasteur and I have been appointed Co-director of the Institut Pasteur Microbiology Course in 2014.
ADMINISTRATIVE RESPONSIBILITIES and EXPERTISE
2015-present Group leader within the Genetics of Biofilms Unit
Academic Editor PLoS One, Review in Frontiers in Cellular and Infection Microbiology and Reviewer
for > 20 journals and funding agencies
MAIN RECENT RESEARCH FUNDING
- 2014-2017 FRM Team. Study of bacterial biofilm formation. 270k€. Co-investigator
- 2016 Center for Translational Research Institut Pasteur. Pharmalock. 30k€. Co-investigator
- 2016 PEPS FAIDORA CNRS. Evaluation des signes précurseurs de la nanotoxicité de dendrimères sur
bactéries : de la nanoparticule unique à l’effet populationnel – nanodUP. 15k€. Partner.
- 2017-2019 PTR Institut Pasteur – A multi-disciplinary investigation of the Negativicutes: atypical
Firmicutes with LPS-outer membranes that inhibit the human gut. 60 k€. Partner.
- 2017-2020 French National Research Agency (ANR) – Firmicutes with an outer membrane: toward new
models to study the diderm/monoderm cell envelope transition. 183 k€. Partner.
- 2018-2022 French National Research Agency (ANR) – Evolution and dynamics of dissemination of
Tolerance towards AntiBiotics in biofilms. 320 k€. PI.
ADMINISTRATIVE RESPONSIBILITIES and EXPERTISE
2015-present Group leader within the Genetics of Biofilms Unit
Academic Editor PLoS One, Review in Frontiers in Cellular and Infection Microbiology and Reviewer
for > 20 journals and funding agencies
MAIN RECENT RESEARCH FUNDING
- 2014-2017 FRM Team. Study of bacterial biofilm formation. 270k€. Co-investigator
- 2016 Center for Translational Research Institut Pasteur. Pharmalock. 30k€. Co-investigator
- 2016 PEPS FAIDORA CNRS. Evaluation des signes précurseurs de la nanotoxicité de dendrimères sur
bactéries : de la nanoparticule unique à l’effet populationnel – nanodUP. 15k€. Partner.
- 2017-2019 PTR Institut Pasteur – A multi-disciplinary investigation of the Negativicutes: atypical
Firmicutes with LPS-outer membranes that inhibit the human gut. 60 k€. Partner.
- 2017-2020 French National Research Agency (ANR) – Firmicutes with an outer membrane: toward new
models to study the diderm/monoderm cell envelope transition. 183 k€. Partner.
- 2018-2022 French National Research Agency (ANR) – Evolution and dynamics of dissemination of
Tolerance towards AntiBiotics in biofilms. 320 k€. PI.
研究兴趣
论文共 123 篇作者统计合作学者相似作者
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Augustinas Silale,Yiling Zhu,Jerzy Witwinowski, Robert E. Smith,Kahlan E. Newman, Satya P. Bhamidimarri,Arnaud Baslé,Syma Khalid,Christophe Beloin,Simonetta Gribaldo,Bert van den Berg
Microbiology spectrumno. 4 (2023): e0176723-e0176723
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Kyrie P Grasekamp, Basile Beaud Benyahia,Najwa Taib, Bianca Audrain,Benjamin Bardiaux,Yannick Rossez,Nadia Izadi-Pruneyre, Maylis Lejeune,Xavier Trivelli, Zina Chouit,Yann Guerardel, Jean-Marc Ghigo,
Nature communicationsno. 1 (2023): 7642-7642
biorxiv(2023)
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
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JOURNAL OF INFECTIOUS DISEASES (2023)
Joaquín Bernal-Bayard, Jérôme Thiebaud,Marina Brossaud,Audrey Beaussart,Céline Caillet,Yves Waldvogel,Laetitia Travier,Sylvie Létoffé,Thierry Fontaine,Bachra Rokbi, Philippe Talaga,Christophe Beloin,
biorxiv(2023)
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