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Since completion of my Wellcome Trust Advanced Fellowship, I have been involved in the Wellcome Trust Case Control Consortium study to perform a genome-wide investigation for 7 common diseases, including rheumatoid arthritis, which was published in Nature. Excitingly, a novel rheumatoid arthritis susceptibility locus was detected and confirmed in replication studies leading to a further high-profile publication. Work is underway to identify the causal variant and determine how it contributes to disease.
I have a program of work in pharmacogenetics, particulalry in predicting response to treatment in patients receiving biologic therapies for their arthritic diseases. I have established the Biologics in RA Genetics and Genomics Study Syndicate (BRAGGSS), comprising the rheumatologists at the larger prescribing centres across the UK, and co-ordinate the collection of DNA samples from patients treated with these agents at these centres. The collection is now by far the largest in the world (approximately 4,000 patients with DNA and >1,000 with additional samples, e.g. RNA) and represents a unique resource because of the richness of the phenotypic data available.
I have a strong interest in the genetic presdisposition to psoriatic arthritis, the second most common of the inflammatory arthritic diseases. I lead a UK consortium trying to identify susceptibility genes and I chair the PAGE (Psoriatic Arthritis Genetic European) consortium to establish a European-wide collaboration to take this field of research forward.
I have a program of work in pharmacogenetics, particulalry in predicting response to treatment in patients receiving biologic therapies for their arthritic diseases. I have established the Biologics in RA Genetics and Genomics Study Syndicate (BRAGGSS), comprising the rheumatologists at the larger prescribing centres across the UK, and co-ordinate the collection of DNA samples from patients treated with these agents at these centres. The collection is now by far the largest in the world (approximately 4,000 patients with DNA and >1,000 with additional samples, e.g. RNA) and represents a unique resource because of the richness of the phenotypic data available.
I have a strong interest in the genetic presdisposition to psoriatic arthritis, the second most common of the inflammatory arthritic diseases. I lead a UK consortium trying to identify susceptibility genes and I chair the PAGE (Psoriatic Arthritis Genetic European) consortium to establish a European-wide collaboration to take this field of research forward.
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RHEUMATOLOGYno. 4 (2024): 1015-1021
ANNALS OF THE RHEUMATIC DISEASESno. 3 (2024): 288-299
Ali Al-Janabi,Paul Martin, Catherine Simpson, Hefin Rhys,Adnan Khan,Steve Eyre, Maria Christofi,Amy Foulkes,Andrew Skelton,Sebastien Viatte,Anne Barton, Andrew Morris,
British Journal of Dermatologyno. 6 (2024)
RHEUMATOLOGYno. Supplement_2 (2023)
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