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Over my career, my clinical and investigational work has focused on the treatment of heart and lung end-stage diseases. I have approached that task by combining heart and lung transplantation with the developments in total artificial heart, ventricular assist devices, ECMO, and now ambulatory ECMO. To do so, I established the McGowan Center for Artificial Organ Development at the University of Pittsburgh, which was a $10 million philanthropic effort resulting in the multi-use free-standing facility. I have continued my investigative work and, since 1986, have been continuously funded as a principal investigator by the NIH. Work continued in an ambulatory artificial lung, which first was funded in 1990, and has used more than $20 million of NIH support. The device once imagined on a napkin is now cleared by the FDA for clinical use, and the role-out of the Breethe system designed for home use will begin in the next few months. The work on this system evolved with clinical input from experiences in patients with end-stage respiratory distress but also included multi-disciplinary input from a broad array of experts in the bioengineering aspects of the project. Recently, my funding has extended to include clinical program director for xenotransplantation of the heart. This program’s ongoing focus has been the outcome in genetically engineered swine hearts when placed in baboons. Success with that program (survivals in excess of 150 days and ongoing) suggests that clinical implementation may be appropriate soon. Throughout my career I have been a mentor of cardiothoracic surgical trainees and other post doc engineers.
研究兴趣
论文共 889 篇作者统计合作学者相似作者
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Mahdokht Parsirad, Oneib Khan,Bartley P. Griffith, Likhitesh Jaikumar,Monodeep Biswas, Mohsan Chaudhry,Manjula Ananthram, Susie Nam Hong-Zohlman,Alison Grazioli,Avneesh K. Singh,Richard Amara,Stephen Ross Shorofsky,
Journal of the American College of Cardiologyno. 13 (2024)
Timm Dickfeld,Calvin Kagan, Richard Amara, Susie Hong-Zohlman,Manjula Ananthram,Charles C. Hong,John Sorkin,Vincent See,Stephen Shorofsky,Bart Griffith,Muhammad Mohiuddin
Robert Choe, Blake Kuzemchak, George Kotsanos,Eman Mirdamadi,Mary Sherry, Eoin Devoy, Tao Lowe,Jonathan D Packer,John P Fisher
Tissue engineering. Part A (2024)
Susie Nam Hong-Zohlman,Muhammad Mohiuddin,Jean Jeudy,Manjula Ananthram,Alison Grazioli,Timm Dickfeld,Peter Hanna,Cullen Soares, Alice Tang,Corbin E. Goerlich, Sadegh Asadi, Albert James Hicks,
Journal of the American College of Cardiologyno. 13 (2024): 1574
Physiological reviews (2024)
Alice Tang,Jean Jeudy,Manjula Ananthram,Cullen Soares,Peter Hanna,Corbin E. Goerlich,Alison Grazioli, Albert James Hicks, Sadegh Asadi,R. Michael Benitez,Timm Dickfeld,Anuj Gupta,
Journal of the American College of Cardiologyno. 13 (2024): 1489
Oneib Khan, Mahdokht Parsirad,Timm Dickfeld,Muhammad Mohiuddin,Avneesh K. Singh,Bartley P. Griffith,Manjula Ananthram, Susie Nam Hong-Zohlman,Stephen Ross Shorofsky,Richard Amara,Alison Grazioli, Mohsan Chaudhry,
Journal of the American College of Cardiologyno. 13 (2024): 222
Doug A. Gouchoe,Pablo G. Sanchez, Jonathan D’Cunha,Christian A. Bermudez,Mani A. Daneshmand,Robert D. Davis,Matthew G. Hartwig,Thomas C. Wozniak,Zachary N. Kon,Bartley P. Griffith,William R. Lynch,Tiago N. Machuca,
The Journal of Thoracic and Cardiovascular Surgery (2024)
Morcos A. Awad, Rafael Cires-Drouet,Gautam Ramani,Joshua L. Leibowitz,Aakash Shah,Christine L. Lau,Bartley P. Griffith
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERYno. 2 (2024): 526-534
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