My research line focusses on the pathogenesis of viral infections and especially those viruses that emerge through zoonotic transmission. This brings together work performed earlier at the Veterinary faculty in Utrecht and more recent work on human viruses in Rotterdam. Over the last five years we have characterised the genome of Middle East respiratory syndrome (MERS) coronavirus, identified the receptor used by this virus and contributed to the identification of the dromedary camel as the reservoir species. We have tested a vaccine candidate that reduces the transmission of MERS-CoV by vaccinating dromedary camels. These studies led to a more detailed understanding of the biology of this emerging virus and led to novel intervention strategies to contain the outbreak.